Verify Sildenafil

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "sildenafil",
  "nameEn": "Sildenafil",
  "nameTh": "ซิลเดนาฟิล",
  "class": "Cardiovascular — PDE5 inhibitor (pulmonary hypertension)",
  "mechanism": "ยับยั้ง phosphodiesterase-5 (PDE5) เพิ่ม cGMP ทำให้หลอดเลือดในปอดขยายตัว ลดความดันหลอดเลือดแดงปอด; เป็นยาหลักรักษา pulmonary hypertension ในสุนัข",
  "brandNamesTh": [
    "Viagra",
    "Revatio"
  ],
  "indications": [
    {
      "text": "รักษา pulmonary hypertension ในสุนัข (เช่น จาก degenerative mitral valve disease, heartworm, idiopathic); ช่วยลดอาการเหนื่อย/เป็นลม (syncope)",
      "cites": [
        "merck-ph",
        "paper-sildenafil"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามใช้ร่วมกับ nitrates (ความดันตกรุนแรง); ระวังในภาวะความดันต่ำ; ปรับลดในตับ/ไตบกพร่อง",
      "cites": [
        "merck-ph"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ความดันต่ำ, หน้าแดง, GI upset; โดยรวมทนได้ดีในสุนัข",
      "cites": [
        "merck-ph"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Pulmonary hypertension",
      "route": "PO",
      "dose": "1–3 mg/kg PO ทุก 8–12 ชั่วโมง",
      "cites": [
        "merck-ph",
        "paper-sildenafil"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-ph",
      "type": "textbook",
      "title": "Systemic and Pulmonary Hypertension in Dogs and Cats — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/circulatory-system/various-cardiovascular-diseases-in-dogs-and-cats/systemic-and-pulmonary-hypertension-in-dogs-and-cats",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "paper-sildenafil",
      "type": "paper",
      "title": "Clinical Efficacy of Sildenafil in Treatment of Pulmonary Arterial Hypertension in Dogs (Brown 2010, JVIM)",
      "url": "https://onlinelibrary.wiley.com/doi/10.1111/j.1939-1676.2010.0517.x",
      "year": 2021,
      "note": "Peer-reviewed efficacy study, canine PAH.",
      "cid": null
    },
    {
      "id": "wikipedia-Sildenafil",
      "type": "monograph",
      "title": "Sildenafil — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Sildenafil",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "C02KX01",
      "name": "Sildenafil (PAH)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / AAHA + ACVIM guidelines / peer-reviewed studies), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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