Verify Sevoflurane

Drug JSON

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{
  "slug": "sevoflurane",
  "nameEn": "Sevoflurane",
  "nameTh": "เซโวฟลูเรน",
  "class": "Inhalation general anesthetic — halogenated ether",
  "mechanism": "ยาดมสลบชนิดสูดที่ละลายในเลือดต่ำกว่า isoflurane จึงเหนี่ยวนำและฟื้นเร็วกว่า กลิ่นไม่ฉุน เหมาะกับ mask induction",
  "brandNamesTh": [
    "SevoFlo",
    "Sevorane"
  ],
  "indications": [
    {
      "text": "การเหนี่ยวนำ (รวม mask induction) และคงระดับการสลบทั่วไป — ฟื้นเร็ว เหมาะกับเคสที่ต้องการควบคุมระดับการสลบละเอียด",
      "cites": [
        "dailymed-sevoflurane",
        "plumbs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "malignant hyperthermia susceptibility; ใช้ด้วยความระวังในสัตว์ที่ระบบไหลเวียนไม่คงที่",
      "cites": [
        "dailymed-sevoflurane",
        "plumbs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ความดันตกตามขนาด, กดการหายใจ, อุณหภูมิกายต่ำ; ทำปฏิกิริยากับ soda lime ได้ compound A (พิษไตในทางทฤษฎี ความสำคัญทางคลินิกต่ำ)",
      "cites": [
        "plumbs",
        "wikipedia-Sevoflurane"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "General anesthesia (induction/maintenance)",
      "route": "inhaled",
      "dose": "เหนี่ยวนำ 4–7%, คงระดับ 2.5–4% ในออกซิเจน (MAC สุนัข ~2.4%)",
      "cites": [
        "plumbs",
        "dailymed-sevoflurane"
      ]
    },
    {
      "species": "feline",
      "indication": "General anesthesia (induction/maintenance)",
      "route": "inhaled",
      "dose": "คงระดับ 2.5–4% (MAC แมว ~2.6%)",
      "cites": [
        "plumbs"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-N01AB08",
      "type": "regulatory-database",
      "title": "WHO ATC/DDD Index — Sevoflurane (N01AB08)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=N01AB08&showdescription=no",
      "note": "WHO Anatomical Therapeutic Chemical classification. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "dailymed-sevoflurane",
      "type": "package-insert",
      "title": "Sevoflurane — DailyMed (US FDA label)",
      "year": 2026,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=sevoflurane",
      "note": "US FDA structured product label. Authoritative for indications, contraindications, labeled use.",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Species doses cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "wikipedia-Sevoflurane",
      "type": "monograph",
      "title": "Sevoflurane — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Sevoflurane",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "N01AB08",
      "name": "Sevoflurane",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (WHO ATC / FDA label / Plumb’s / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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