Verify Sarolaner

Drug JSON

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{
  "slug": "sarolaner",
  "nameEn": "Sarolaner",
  "nameTh": "ซาโรลาเนอร์",
  "class": "Antiparasitic — isoxazoline (monthly flea & tick)",
  "mechanism": "ยากำจัดหมัดและเห็บกลุ่ม isoxazoline ปิดกั้น GABA-gated chloride channel ของปรสิต; ออกฤทธิ์รายเดือน (สั้นกว่า fluralaner)",
  "brandNamesTh": [
    "Simparica",
    "Simparica Trio"
  ],
  "indications": [
    {
      "text": "กำจัดและป้องกันหมัดและเห็บในสุนัขแบบรายเดือน (PO); รูปแบบ Simparica Trio รวม moxidectin + pyrantel ครอบคลุมพยาธิหนอนหัวใจและลำไส้",
      "cites": [
        "fda-simparica",
        "fda-isoxazoline-b"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ คำเตือน FDA เรื่องเหตุการณ์ทางระบบประสาทในกลุ่ม isoxazoline — ระวังในสัตว์ที่มีประวัติชัก",
      "cites": [
        "fda-isoxazoline-b"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "อาเจียน ท้องเสีย; เหตุการณ์ทางระบบประสาท (สั่น ชัก เดินเซ) พบน้อยตามคำเตือนกลุ่ม isoxazoline",
      "cites": [
        "fda-isoxazoline-b"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Flea & tick (monthly)",
      "route": "PO",
      "dose": "2–4 mg/kg PO ทุกเดือน (ขั้นต่ำตามฉลาก 2 mg/kg)",
      "cites": [
        "fda-simparica"
      ]
    }
  ],
  "citations": [
    {
      "id": "fda-simparica",
      "type": "package-insert",
      "title": "Simparica (sarolaner) — FDA-approved veterinary label",
      "year": 2025,
      "url": "https://www.drugs.com/vet/simparica.html",
      "note": "FDA-approved veterinary product label. Public FDA labeling.",
      "cid": null
    },
    {
      "id": "fda-isoxazoline-b",
      "type": "guideline",
      "title": "FDA Fact Sheet — isoxazoline flea/tick neurologic adverse events",
      "year": 2024,
      "url": "https://www.fda.gov/animal-veterinary/animal-health-literacy/fact-sheet-pet-owners-and-veterinarians-about-potential-adverse-events-associated-isoxazoline-flea",
      "note": "FDA safety communication on isoxazoline class.",
      "cid": null
    },
    {
      "id": "wikipedia-Sarolaner",
      "type": "monograph",
      "title": "Sarolaner — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Sarolaner",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "QP53BE03",
      "name": "Sarolaner",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / peer-reviewed studies), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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