Verify S-Adenosylmethionine (SAMe)

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "sam-e",
  "nameEn": "S-Adenosylmethionine (SAMe)",
  "nameTh": "เอส-อะดีโนซิลเมไทโอนีน (SAMe)",
  "class": "Metabolic / hepatoprotectant — glutathione precursor",
  "mechanism": "สารตั้งต้นในการสร้าง glutathione (สารต้านอนุมูลอิสระหลักของตับ) และเกี่ยวข้องใน transmethylation/transsulfuration; ปกป้องเซลล์ตับจาก oxidative damage; เป็น nutraceutical hepatoprotectant",
  "brandNamesTh": [
    "Denosyl",
    "Denamarin (ร่วม silybin)",
    "Zentonil"
  ],
  "indications": [
    {
      "text": "สนับสนุนและปกป้องตับ (hepatoprotection) ในโรคตับเรื้อรัง, ตับเป็นพิษจากยา (เช่น acetaminophen, lomustine, azole), และภาวะ oxidative liver injury ในสุนัขและแมว; มักให้ร่วม silybin (Denamarin)",
      "cites": [
        "petplace-same",
        "merck-hepatoprotect"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "โดยรวมปลอดภัยมาก (nutraceutical); ให้ตอนท้องว่าง (เพิ่มการดูดซึม) และเก็บเม็ดในแผง (ดูดความชื้น)",
      "cites": [
        "petplace-same"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "พบน้อยมาก; อาจมี GI upset เล็กน้อย",
      "cites": [
        "petplace-same"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Hepatoprotection / liver support",
      "route": "PO",
      "dose": "18–20 mg/kg PO วันละครั้ง ตอนท้องว่าง",
      "cites": [
        "petplace-same",
        "merck-hepatoprotect"
      ]
    },
    {
      "species": "feline",
      "indication": "Hepatoprotection / liver support",
      "route": "PO",
      "dose": "~20 mg/kg PO วันละครั้ง ตอนท้องว่าง (มักใช้ 90 mg/ตัว)",
      "cites": [
        "petplace-same"
      ]
    }
  ],
  "citations": [
    {
      "id": "petplace-same",
      "type": "monograph",
      "title": "S-Adenosylmethionine (SAMe) for Dogs and Cats — PetPlace",
      "url": "https://www.petplace.com/article/drug-library/drug-library/library/s-adenosylmethionine-same-for-dogs-and-cats",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "merck-hepatoprotect",
      "type": "textbook",
      "title": "Hepatic Disease — Hepatoprotectants — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/digestive-system/hepatic-diseases-of-small-animals/treatment-of-hepatic-disease-in-small-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-s-adenosyl_methionine",
      "type": "monograph",
      "title": "S-Adenosylmethionine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/S-Adenosyl_methionine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "A16AA90",
      "name": "Ademetionine (SAMe)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VIN / PetPlace / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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