Verify Rifampicin (rifampin)

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "rifampicin",
  "nameEn": "Rifampicin (rifampin)",
  "nameTh": "ไรแฟมพิซิน (ไรแฟมพิน)",
  "class": "Antimycobacterial / antibacterial (rifamycin)",
  "mechanism": "ยับยั้ง DNA-dependent RNA polymerase ของแบคทีเรีย ฤทธิ์ฆ่าเชื้อ ซึมเข้าเซลล์/ฝีได้ดี ใช้กับ Rhodococcus และ staph ลึก — ต้องใช้ร่วมยาอื่นเสมอ (ดื้อยาเร็ว)",
  "brandNamesTh": [
    "Rifadin"
  ],
  "indications": [
    {
      "text": "การติดเชื้อ Rhodococcus equi ในลูกม้า (ร่วม macrolide), staphylococcal pyoderma ลึก/granuloma (adjunct), และ mycobacterial infection — ใช้ร่วมยาอื่นเสมอ",
      "cites": [
        "dailymed-rifampin",
        "plumbs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ห้ามใช้เดี่ยว (เกิดดื้อยาเร็วมาก); พิษต่อตับ (ติดตามเอนไซม์ตับ); เป็น enzyme inducer แรง (CYP450 — drug interaction มาก)",
      "cites": [
        "dailymed-rifampin",
        "plumbs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "พิษตับ, สารคัดหลั่ง/ปัสสาวะ/น้ำตาเป็นสีส้ม-แดง (ปกติ), คลื่นไส้/เบื่ออาหาร, drug interaction จากการเหนี่ยวนำเอนไซม์",
      "cites": [
        "plumbs",
        "wikipedia-Rifampicin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "equine",
      "indication": "Rhodococcus equi (foal, with macrolide)",
      "route": "PO",
      "dose": "5–10 mg/kg PO ทุก 12–24 ชั่วโมง ร่วมกับ macrolide (เช่น clarithromycin/azithromycin)",
      "cites": [
        "plumbs",
        "dailymed-rifampin"
      ]
    },
    {
      "species": "canine",
      "indication": "Deep staphylococcal pyoderma / granuloma (adjunct)",
      "route": "PO",
      "dose": "5–10 mg/kg PO ทุก 12–24 ชั่วโมง ร่วมยาปฏิชีวนะตัวอื่น — ติดตามตับ",
      "cites": [
        "plumbs"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-J04AB02",
      "type": "regulatory-database",
      "title": "WHO ATC/DDD Index — Rifampicin (rifampin) (J04AB02)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=J04AB02&showdescription=no",
      "note": "WHO Anatomical Therapeutic Chemical classification. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "dailymed-rifampin",
      "type": "package-insert",
      "title": "Rifampin — DailyMed (FDA label)",
      "year": 2026,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=rifampin",
      "note": "FDA structured product label (human or veterinary). Authoritative for indications, contraindications, labeled use.",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Species doses cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "wikipedia-Rifampicin",
      "type": "monograph",
      "title": "Rifampicin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Rifampicin",
      "note": "Tertiary cross-check for class + mechanism + ATC code. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "J04AB02",
      "name": "Rifampicin (rifampin)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (WHO ATC / FDA label / Plumb’s), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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