Verify Quinidine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "quinidine",
  "nameEn": "Quinidine",
  "nameTh": "ควินิดีน",
  "class": "Cardiovascular — class Ia antiarrhythmic",
  "mechanism": "class Ia antiarrhythmic — ปิดกั้น sodium channel + ฤทธิ์ vagolytic; ใช้แปลง atrial fibrillation กลับเป็น sinus rhythm (cardioversion) เป็นหลัก",
  "brandNamesTh": [
    "Quinidine sulfate/gluconate"
  ],
  "indications": [
    {
      "text": "แปลง atrial fibrillation กลับเป็น normal sinus rhythm (chemical cardioversion) ในสุนัข (โดยเฉพาะ AF ที่ไม่มีโรคหัวใจโครงสร้าง) และในม้า",
      "cites": [
        "merck-antiarrhythmic-q4",
        "tufts-quinidine"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ proarrhythmia (torsades/QT ยาว), ฤทธิ์ vagolytic เพิ่ม ventricular rate (ใน AF ต้องคุม rate ก่อน), เพิ่มระดับ digoxin (drug interaction); GI upset เด่น; ห้ามใน AV block; ระวังในโรคหัวใจโครงสร้าง",
      "cites": [
        "merck-antiarrhythmic-q4",
        "tufts-quinidine"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "GI upset (ท้องเสีย อาเจียน — เด่น), proarrhythmia/QT prolongation, ความดันต่ำ, เพิ่ม digoxin level",
      "cites": [
        "merck-antiarrhythmic-q4"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Atrial fibrillation cardioversion",
      "route": "PO",
      "dose": "quinidine sulfate 6–20 mg/kg PO ทุก 6–8 ชั่วโมง; gluconate 6–20 mg/kg IM ทุก 6 ชม. — ส่วนใหญ่แปลงภายใน 24 ชม.",
      "cites": [
        "merck-antiarrhythmic-q4",
        "tufts-quinidine"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ECG (QT/proarrhythmia + ventricular rate); ระดับ digoxin หากใช้ร่วม",
      "cites": [
        "merck-antiarrhythmic-q4"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-antiarrhythmic-q4",
      "type": "textbook",
      "title": "Antiarrhythmics for Use in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-cardiovascular-system/antiarrhythmics-for-use-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "tufts-quinidine",
      "type": "guideline",
      "title": "Quinidine — Tufts CardioRush Cardiology Drug Formulary",
      "url": "https://sites.tufts.edu/cardiorush/cardiology-drug-formulary/",
      "year": 2024,
      "note": "Tufts cardiology reference dosing.",
      "cid": null
    },
    {
      "id": "wikipedia-quinidine",
      "type": "monograph",
      "title": "Quinidine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Quinidine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "C01BA01",
      "name": "Quinidine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / Tufts CardioRush / FDA labels / VCA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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