Verify Propranolol

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "propranolol",
  "nameEn": "Propranolol",
  "nameTh": "โพรพราโนลอล",
  "class": "Cardiovascular — non-selective beta blocker",
  "mechanism": "ปิดกั้น beta-1 และ beta-2 adrenergic receptor (non-selective) ลดอัตราและแรงบีบหัวใจ ลดความต้องการออกซิเจน และคุมการเต้นผิดจังหวะ; ลดอาการ tachycardia จากไทรอยด์เป็นพิษ",
  "brandNamesTh": [
    "Inderal"
  ],
  "indications": [
    {
      "text": "หัวใจเต้นผิดจังหวะ (supraventricular tachycardia, atrial fibrillation/flutter, PVC), tachycardia จาก hyperthyroidism (แมว) และ pheochromocytoma ในสุนัขและแมว",
      "cites": [
        "merck-antiarrhythmic-j",
        "vca-propranolol"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ห้าม/ระวังในโรคทางเดินหายใจ (asthma — beta-2 block ทำหลอดลมหด), หัวใจล้มเหลวที่ยังไม่คุม, bradycardia/AV block; ห้ามหยุดกะทันหัน (rebound); ระวังในเบาหวาน (บัง hypoglycemia)",
      "cites": [
        "merck-antiarrhythmic-j",
        "vca-propranolol"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "หัวใจเต้นช้า, ความดันต่ำ, หลอดลมหดเกร็ง, ซึม/อ่อนแรง, แย่ลงใน CHF ที่ไม่คุม",
      "cites": [
        "vca-propranolol"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Arrhythmia (titrate)",
      "route": "PO",
      "dose": "0.2–1 mg/kg PO ทุก 8 ชั่วโมง (เริ่มต่ำ titrate ตามผล)",
      "cites": [
        "merck-antiarrhythmic-j",
        "vca-propranolol"
      ]
    },
    {
      "species": "feline",
      "indication": "Arrhythmia / hyperthyroid tachycardia",
      "route": "PO",
      "dose": "0.4–1.2 mg/kg (2.5–5 mg/ตัว) PO ทุก 8 ชั่วโมง",
      "cites": [
        "vca-propranolol"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-antiarrhythmic-j",
      "type": "textbook",
      "title": "Antiarrhythmics for Use in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-cardiovascular-system/antiarrhythmics-for-use-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "vca-propranolol",
      "type": "monograph",
      "title": "Propranolol — VCA Animal Hospitals",
      "url": "https://vcahospitals.com/know-your-pet/propranolol",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-propranolol",
      "type": "monograph",
      "title": "Propranolol — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Propranolol",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "C07AA05",
      "name": "Propranolol",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VSSO / CURATIVE / Tufts CardioRush / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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