Verify Prochlorperazine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "prochlorperazine",
  "nameEn": "Prochlorperazine",
  "nameTh": "โพรคลอร์เพอราซีน",
  "class": "Anti-emetic — phenothiazine (also sedative)",
  "mechanism": "phenothiazine — ปิดกั้น dopamine (D2) receptor ที่ chemoreceptor trigger zone (CRTZ) ระงับอาเจียนได้แรง + มีฤทธิ์สงบประสาท; กลุ่มเดียวกับ acepromazine",
  "brandNamesTh": [
    "Compazine",
    "Stemetil"
  ],
  "indications": [
    {
      "text": "อาเจียน/คลื่นไส้ในสุนัขและแมว (โดยเฉพาะ motion sickness, อาเจียนทั่วไป) — phenothiazine antiemetic; ⚠️ maropitant/metoclopramide เป็นทางเลือกแรกกว่า",
      "cites": [
        "petplace-prochlorperazine",
        "merck-emesis-s"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวัง hypotension (ฤทธิ์ alpha-block ของ phenothiazine), sedation, extrapyramidal signs (rigidity/tremor); ห้าม/ระวังในภาวะขาดน้ำ-ช็อก (ความดันตก); ระวังในสัตว์ชัก (ลด seizure threshold)",
      "cites": [
        "petplace-prochlorperazine"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ซึม, ความดันต่ำ, extrapyramidal (rigidity tremor weakness restlessness)",
      "cites": [
        "petplace-prochlorperazine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Vomiting / nausea",
      "route": "IM",
      "dose": "0.1–0.5 mg/kg IM/SC/IV ทุก 6–8 ชั่วโมง; PO 0.5–1 mg/kg ทุก 8–12 ชั่วโมง",
      "cites": [
        "petplace-prochlorperazine",
        "merck-emesis-s"
      ]
    },
    {
      "species": "feline",
      "indication": "Vomiting / nausea",
      "route": "IM",
      "dose": "0.1–0.5 mg/kg IM/SC ทุก 6–8 ชั่วโมง",
      "cites": [
        "petplace-prochlorperazine"
      ]
    }
  ],
  "citations": [
    {
      "id": "petplace-prochlorperazine",
      "type": "monograph",
      "title": "Prochlorperazine (Compazine) for Dogs and Cats — PetPlace",
      "url": "https://www.petplace.com/article/drug-library/drug-library/library/prochlorperazine-compazine-prochlorperazine-for-dogs-and-cats",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "merck-emesis-s",
      "type": "textbook",
      "title": "Drugs Used to Control or Stimulate Vomiting in Monogastric Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-digestive-system/drugs-used-to-control-or-stimulate-vomiting-in-monogastric-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-prochlorperazine",
      "type": "monograph",
      "title": "Prochlorperazine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Prochlorperazine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "N05AB04",
      "name": "Prochlorperazine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VCA / EveryCat / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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