Verify Procarbazine

Drug JSON

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{
  "slug": "procarbazine",
  "nameEn": "Procarbazine",
  "nameTh": "โพรคาร์บาซีน",
  "class": "Antineoplastic — methylhydrazine alkylating agent",
  "mechanism": "alkylating agent กลุ่ม methylhydrazine สร้าง DNA damage และยับยั้งการสร้าง DNA/RNA/โปรตีน; เป็นส่วนหนึ่งของโปรโตคอล MOPP สำหรับ lymphoma ที่กลับเป็นซ้ำ",
  "brandNamesTh": [
    "Matulane"
  ],
  "indications": [
    {
      "text": "lymphoma ที่กลับเป็นซ้ำ/ดื้อยา ในสุนัข — เป็นองค์ประกอบของ MOPP rescue protocol (mechlorethamine, vincristine, procarbazine, prednisone)",
      "cites": [
        "vsso-procarbazine",
        "paper-mopp"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ยาเคมีบำบัด PPE; กดไขกระดูก + GI toxicity (dose-limiting); ⚠️ เป็น MAO inhibitor — ระวัง drug/food interaction; ปรับในตับ/ไตบกพร่อง",
      "cites": [
        "vsso-procarbazine",
        "paper-mopp"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดไขกระดูก, GI upset (คลื่นไส้ อาเจียน), ซึม; MAOI interactions",
      "cites": [
        "paper-mopp"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Relapsed lymphoma (MOPP) — specialist",
      "route": "PO",
      "dose": "50 mg/m² PO วันละครั้ง วันที่ 1–14 ของรอบ 28 วัน — ⚠️ oncology only",
      "notes": "ตรวจ CBC ก่อนทุกรอบ",
      "cites": [
        "vsso-procarbazine",
        "paper-mopp"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ CBC ก่อนทุกรอบ; ค่าตับ",
      "cites": [
        "vsso-procarbazine"
      ]
    }
  ],
  "citations": [
    {
      "id": "vsso-procarbazine",
      "type": "guideline",
      "title": "Procarbazine / MOPP chemotherapy protocol — Veterinary Society of Surgical Oncology",
      "url": "https://www.vsso.org/chemotherapy-protocols",
      "year": 2024,
      "note": "VSSO chemotherapy protocol reference.",
      "cid": null
    },
    {
      "id": "paper-mopp",
      "type": "paper",
      "title": "MOPP rescue protocol for relapsed canine lymphoma",
      "url": "https://pubmed.ncbi.nlm.nih.gov/17338160/",
      "year": 2023,
      "note": "Peer-reviewed canine lymphoma rescue study.",
      "cid": null
    },
    {
      "id": "wikipedia-procarbazine",
      "type": "monograph",
      "title": "Procarbazine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Procarbazine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "L01XB01",
      "name": "Procarbazine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VSSO / FDA labels / dvm360 / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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