Verify Procaine benzylpenicillin (procaine penicillin G)

Drug JSON

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{
  "slug": "procaine-penicillin",
  "nameEn": "Procaine benzylpenicillin (procaine penicillin G)",
  "nameTh": "โพรเคน เพนิซิลลิน จี",
  "class": "Beta-lactamase sensitive penicillin (repository/long-acting)",
  "mechanism": "penicillin G รูปเกลือ procaine ที่ปลดปล่อยช้าจากกล้ามเนื้อ คงระดับยานานขึ้น ฆ่าแบคทีเรียแกรมบวกและ anaerobe บางชนิด",
  "brandNamesTh": [
    "Procaine Penicillin G"
  ],
  "indications": [
    {
      "text": "การติดเชื้อแกรมบวกที่ไวต่อ penicillin (เช่น Streptococcus, Clostridium) ในปศุสัตว์และม้า — ออกฤทธิ์ต่อเนื่องจากการดูดซึมช้า",
      "cites": [
        "dailymed-procaine penicillin",
        "plumbs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "แพ้ penicillin; ⚠️ ห้ามฉีด IV (procaine เป็นพิษต่อหัวใจ/ระบบประสาท); ระวังปฏิกิริยา procaine; เว้นระยะหยุดยาในสัตว์ผลิตอาหาร",
      "cites": [
        "dailymed-procaine penicillin",
        "plumbs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "อาการแพ้, ปฏิกิริยา procaine (ตื่นเต้น/ชัก/ล้มถ้าเข้าหลอดเลือด), เจ็บบริเวณฉีด",
      "cites": [
        "plumbs",
        "wikipedia-Procaine_benzylpenicillin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "bovine",
      "indication": "Gram-positive infection",
      "route": "IM",
      "dose": "20,000–40,000 IU/kg IM ทุก 12–24 ชั่วโมง (เฉพาะ IM ห้าม IV)",
      "cites": [
        "plumbs",
        "dailymed-procaine penicillin"
      ]
    },
    {
      "species": "equine",
      "indication": "Gram-positive infection",
      "route": "IM",
      "dose": "20,000–25,000 IU/kg IM ทุก 12 ชั่วโมง",
      "cites": [
        "plumbs"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-J01CE09",
      "type": "regulatory-database",
      "title": "WHO ATC/DDD Index — Procaine benzylpenicillin (J01CE09)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=J01CE09&showdescription=no",
      "note": "WHO Anatomical Therapeutic Chemical classification. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "dailymed-procaine penicillin",
      "type": "package-insert",
      "title": "Procaine penicillin G — DailyMed (US FDA label)",
      "year": 2026,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=procaine%20penicillin",
      "note": "US FDA structured product label. Authoritative for indications, contraindications, labeled use.",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Species doses cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "wikipedia-Procaine_benzylpenicillin",
      "type": "monograph",
      "title": "Procaine benzylpenicillin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Procaine_benzylpenicillin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "J01CE09",
      "name": "Procaine benzylpenicillin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (WHO ATC / FDA label / Plumb’s), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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