Verify Pregabalin

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "pregabalin",
  "nameEn": "Pregabalin",
  "nameTh": "พรีกาบาลิน",
  "class": "Anticonvulsant / analgesic — alpha-2-delta calcium channel ligand",
  "mechanism": "จับ alpha-2-delta subunit ของ voltage-gated calcium channel ลดการปล่อย neurotransmitter ที่กระตุ้น จึงลดการชัก ความปวดประสาท และความวิตกกังวล (gabapentinoid รุ่นที่แรงและดูดซึมแน่นอนกว่า gabapentin)",
  "brandNamesTh": [
    "Lyrica",
    "Bonqat"
  ],
  "indications": [
    {
      "text": "การชักที่ดื้อยา (add-on), ความปวดประสาท (neuropathic pain), และความเครียด/วิตกกังวลในแมว (Bonqat รูปน้ำกินรับรองสำหรับลดความเครียดก่อนเดินทาง/พบสัตวแพทย์)",
      "cites": [
        "merck-anticonvulsant-h",
        "ema-bonqat"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามหยุดยากะทันหัน (เสี่ยงชัก rebound — ค่อย ๆ ลด); ปรับขนาดในไตบกพร่อง (ขับทางไต); ระวัง sedation; เป็นยาควบคุมในบางประเทศ",
      "cites": [
        "merck-anticonvulsant-h"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ง่วงซึม เดินเซ (ataxia) โดยเฉพาะช่วงแรก, น้ำหนักขึ้นเมื่อใช้นาน",
      "cites": [
        "ema-bonqat"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Refractory seizures / neuropathic pain",
      "route": "PO",
      "dose": "3–4 mg/kg PO ทุก 8–12 ชั่วโมง (เริ่มต่ำแล้วค่อยปรับขึ้นลด sedation)",
      "cites": [
        "merck-anticonvulsant-h"
      ]
    },
    {
      "species": "feline",
      "indication": "Transport / veterinary-visit anxiety (Bonqat)",
      "route": "PO",
      "dose": "5 mg/kg PO ครั้งเดียว ~1.5 ชม. ก่อนเหตุการณ์ (Bonqat oral solution)",
      "cites": [
        "ema-bonqat"
      ]
    },
    {
      "species": "feline",
      "indication": "Neuropathic pain / seizures",
      "route": "PO",
      "dose": "1–2 mg/kg PO ทุก 12 ชั่วโมง",
      "cites": [
        "merck-anticonvulsant-h"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-anticonvulsant-h",
      "type": "textbook",
      "title": "Anticonvulsants — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-nervous-system/anticonvulsants-in-monogastric-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "ema-bonqat",
      "type": "package-insert",
      "title": "Bonqat (pregabalin oral solution for cats) — EMA veterinary label",
      "year": 2025,
      "url": "https://www.ema.europa.eu/en/medicines/veterinary/EPAR/bonqat",
      "note": "FDA/EMA-approved veterinary product label. Public regulatory labeling.",
      "cid": null
    },
    {
      "id": "wikipedia-pregabalin",
      "type": "monograph",
      "title": "Pregabalin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Pregabalin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "N03AX16",
      "name": "Pregabalin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / EMA-FDA labels / VSSO / ACVIM-AAHA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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