Verify Prednisone

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "prednisone",
  "nameEn": "Prednisone",
  "nameTh": "เพรดนิโซน",
  "class": "Corticosteroid — glucocorticoid prodrug (→ prednisolone)",
  "mechanism": "glucocorticoid prodrug ต้องเปลี่ยนเป็น prednisolone ที่ตับจึงออกฤทธิ์; ⚠️ แมวเปลี่ยนได้ไม่ดี จึงควรใช้ prednisolone ในแมวแทน",
  "brandNamesTh": [
    "Deltasone",
    "Sterapred"
  ],
  "indications": [
    {
      "text": "ภาวะอักเสบ ภูมิแพ้ และโรคภูมิคุ้มกัน ในสุนัข (ฤทธิ์เทียบเท่า prednisolone เมื่อตับเปลี่ยนสมบูรณ์)",
      "cites": [
        "merck-glucocorticoid"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ในแมวเปลี่ยนเป็น prednisolone ได้ไม่ดี — ใช้ prednisolone โดยตรงแทน; ข้อห้ามอื่นเหมือน prednisolone (เบาหวาน, ติดเชื้อ, NSAID ร่วม, แผล GI)",
      "cites": [
        "merck-glucocorticoid"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "PU/PD, polyphagia, น้ำหนักขึ้น, ภูมิคุ้มกันลด, iatrogenic Cushing; ประสิทธิภาพในแมวด้อยกว่า prednisolone",
      "cites": [
        "merck-glucocorticoid"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Anti-inflammatory / immunosuppressive",
      "route": "PO",
      "dose": "anti-inflammatory 0.5–1 mg/kg/วัน; immunosuppressive 2.2–4 mg/kg/วัน (เหมือน prednisolone)",
      "notes": "ในแมวใช้ prednisolone แทน",
      "cites": [
        "merck-glucocorticoid"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-glucocorticoid",
      "type": "textbook",
      "title": "Glucocorticoids / Anti-inflammatory Agents — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/anti-inflammatory-agents/corticosteroids",
      "note": "Merck corticosteroid pharmacology — anti-inflammatory vs immunosuppressive dosing + relative potency. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "dailymed-prednisone",
      "type": "regulatory-database",
      "title": "Prednisone — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=prednisone",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "2f9419f67692f1bfa971fc349c364f99a8dedf8ad42f2d9b6b79b31ee24f2e8d"
    },
    {
      "id": "atc-H02AB07",
      "type": "guideline",
      "title": "ATC H02AB07 — Prednisone",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=H02AB07&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "56ee570195ea715e5268ec3004341486b1d79b88bfa1332d877d53ffa42e5d72"
    },
    {
      "id": "pubchem-prednisone",
      "type": "monograph",
      "title": "Prednisone — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Prednisone",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "7f8d11e4a1fd727653cd886c310b74c08a7cdb183dbe79b6a99f318375105e52"
    },
    {
      "id": "who-eml-22",
      "type": "guideline",
      "title": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "year": 2021,
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "note": "Cross-checked source: drug appears on WHO EML — WHO recognizes its place in basic healthcare.",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=prednisone",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=H02AB07&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Prednisone",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    },
    {
      "id": "who-eml",
      "name": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "asOfDate": "2026-05-27",
      "license": "CC BY-NC-SA 3.0 IGO"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "2f9419f67692f1bfa971fc349c364f99a8dedf8ad42f2d9b6b79b31ee24f2e8d",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "56ee570195ea715e5268ec3004341486b1d79b88bfa1332d877d53ffa42e5d72",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "7f8d11e4a1fd727653cd886c310b74c08a7cdb183dbe79b6a99f318375105e52",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "who-eml",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "H02AB07",
      "name": "Prednisone",
      "level": 5
    },
    "rxnorm": {
      "cui": "8640",
      "name": "Prednisone"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 4 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM), WHO Model List of Essential Medicines (22nd List, 2021)). ATC H02AB07 + RxNorm 8640. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — prednisone dosing + feline poor-conversion warning (use prednisolone) verified against Merck corticosteroids. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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