Verify Prednisolone

Drug JSON

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{
  "slug": "prednisolone",
  "nameEn": "Prednisolone",
  "nameTh": "เพรดนิโซโลน",
  "class": "Corticosteroid — synthetic intermediate-acting glucocorticoid",
  "mechanism": "glucocorticoid สังเคราะห์ออกฤทธิ์ปานกลาง จับ glucocorticoid receptor ลดการอักเสบและกดภูมิคุ้มกันแบบ dose-dependent; เป็น active form (ไม่ต้องเปลี่ยนที่ตับ ต่างจาก prednisone) จึงนิยมในแมว",
  "brandNamesTh": [
    "Prelone",
    "Predforte"
  ],
  "indications": [
    {
      "text": "ภาวะอักเสบและภูมิแพ้ (ขนาด anti-inflammatory) และโรคภูมิคุ้มกันทำลายตนเอง/immune-mediated (ขนาด immunosuppressive); เป็น glucocorticoid ที่ใช้บ่อยที่สุดในสัตว์เล็ก",
      "cites": [
        "merck-glucocorticoid"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวังในเบาหวาน, การติดเชื้อระบบ, แผลในทางเดินอาหาร, ไตวาย; ห้ามใช้ร่วม NSAID (เพิ่มแผล GI); ห้ามหยุดกะทันหันหลังใช้นาน (ค่อย ๆ ลดเพื่อให้ adrenal ฟื้น)",
      "cites": [
        "merck-glucocorticoid"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "PU/PD (ดื่ม/ปัสสาวะมาก), polyphagia, น้ำหนักขึ้น, panting, ภูมิคุ้มกันลด, แผล GI, iatrogenic Cushing เมื่อใช้นาน; แมวทนได้ดีกว่าสุนัข",
      "cites": [
        "merck-glucocorticoid"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Anti-inflammatory",
      "route": "PO",
      "dose": "0.5–1 mg/kg/วัน",
      "cites": [
        "merck-glucocorticoid"
      ]
    },
    {
      "species": "canine",
      "indication": "Immunosuppressive",
      "route": "PO",
      "dose": "2.2 mg/kg ทุก 24 ชั่วโมง (ถึง 6.6 mg/kg/วันในโรครุนแรง) แล้วค่อย ๆ ลด",
      "cites": [
        "merck-glucocorticoid"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-glucocorticoid",
      "type": "textbook",
      "title": "Glucocorticoids / Anti-inflammatory Agents — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/anti-inflammatory-agents/corticosteroids",
      "note": "Merck corticosteroid pharmacology — anti-inflammatory vs immunosuppressive dosing + relative potency. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "dailymed-prednisolone",
      "type": "regulatory-database",
      "title": "Prednisolone — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=prednisolone",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "b29ccc4471804a3c5c97c6b18e0cce026d7a412ca28a99e3a9e3a2edf12b59c5"
    },
    {
      "id": "atc-H02AB06",
      "type": "guideline",
      "title": "ATC H02AB06 — Prednisolone",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=H02AB06&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "8c4ecd460d75910465ee0988e56b2fd1d7a692bfbf158c6af8f3f782a7f6f1f3"
    },
    {
      "id": "pubchem-prednisolone",
      "type": "monograph",
      "title": "Prednisolone — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Prednisolone",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "88421a5287942a6b77844350ca56ab2c60cdcb33d5648cf686077f46665e2c97"
    },
    {
      "id": "who-eml-22",
      "type": "guideline",
      "title": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "year": 2021,
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "note": "Cross-checked source: drug appears on WHO EML — WHO recognizes its place in basic healthcare.",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=prednisolone",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=H02AB06&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Prednisolone",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    },
    {
      "id": "who-eml",
      "name": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "asOfDate": "2026-05-27",
      "license": "CC BY-NC-SA 3.0 IGO"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "b29ccc4471804a3c5c97c6b18e0cce026d7a412ca28a99e3a9e3a2edf12b59c5",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "8c4ecd460d75910465ee0988e56b2fd1d7a692bfbf158c6af8f3f782a7f6f1f3",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "88421a5287942a6b77844350ca56ab2c60cdcb33d5648cf686077f46665e2c97",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "who-eml",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "H02AB06",
      "name": "Prednisolone",
      "level": 5
    },
    "rxnorm": {
      "cui": "8638",
      "name": "Prednisolone"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 4 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM), WHO Model List of Essential Medicines (22nd List, 2021)). ATC H02AB06 + RxNorm 8638. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — anti-inflammatory 0.5–1, immunosuppressive 2.2–6.6 mg/kg/day verified against Merck corticosteroids. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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