Verify Prazosin

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "prazosin",
  "nameEn": "Prazosin",
  "nameTh": "พราโซซิน",
  "class": "Cardiovascular — alpha-1 adrenergic antagonist (smooth-muscle relaxant)",
  "mechanism": "ปิดกั้น alpha-1 adrenergic receptor ทำให้กล้ามเนื้อเรียบคลายตัว — ขยายหลอดเลือด (ลดความดัน) และคลายหูรูดท่อปัสสาวะส่วนใน (internal urethral sphincter)",
  "brandNamesTh": [
    "Minipress"
  ],
  "indications": [
    {
      "text": "คลายหูรูดท่อปัสสาวะในภาวะ functional urethral obstruction/urethral spasm (โดยเฉพาะแมวเพศผู้หลังอุดตัน); ลดความดันโลหิตและ afterload ในบางกรณี",
      "cites": [
        "petplace-prazosin",
        "tvp-uo"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวัง first-dose hypotension/syncope; ภาวะขาดน้ำ; หลักฐานในแมว FUO ยังถกเถียง (บางการศึกษาไม่ลด recurrence)",
      "cites": [
        "tvp-uo"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ความดันต่ำ ซึม อ่อนแรง (โดยเฉพาะ first dose); GI upset",
      "cites": [
        "petplace-prazosin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "feline",
      "indication": "Functional urethral obstruction / urethral spasm",
      "route": "PO",
      "dose": "0.25–0.5 mg/ตัว PO ทุก 12–24 ชั่วโมง (≈ 0.03 mg/kg)",
      "cites": [
        "petplace-prazosin",
        "tvp-uo"
      ]
    },
    {
      "species": "canine",
      "indication": "Urethral spasm",
      "route": "PO",
      "dose": "1 mg/15 kg PO ทุก 8–12 ชั่วโมง",
      "cites": [
        "petplace-prazosin"
      ]
    }
  ],
  "citations": [
    {
      "id": "petplace-prazosin",
      "type": "monograph",
      "title": "Prazosin for Dogs and Cats — PetPlace",
      "url": "https://www.petplace.com/article/drug-library/drug-library/library/prazosin-for-dogs-and-cats",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "tvp-uo",
      "type": "guideline",
      "title": "Feline Urethral Obstruction management — Today's Veterinary Practice",
      "url": "https://todaysveterinarypractice.com/urology-renal-medicine/feline-urethral-obstruction/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-prazosin",
      "type": "monograph",
      "title": "Prazosin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Prazosin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "C02CA01",
      "name": "Prazosin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VSSO / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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