Verify Praziquantel

Drug JSON

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{
  "slug": "praziquantel",
  "nameEn": "Praziquantel",
  "nameTh": "พราซิควอนเทล",
  "class": "Antiparasitic — pyrazinoisoquinoline (cestocide)",
  "mechanism": "ยาฆ่าพยาธิตัวตืด เพิ่มการซึมผ่านของ calcium เข้าผนังพยาธิ ทำให้เกิดการหดเกร็งและทำลาย tegument; ออกฤทธิ์ต่อ cestode (tapeworm) และ trematode",
  "brandNamesTh": [
    "Droncit",
    "Drontal",
    "Profender"
  ],
  "indications": [
    {
      "text": "กำจัดพยาธิตัวตืด (cestode) เช่น Dipylidium caninum, Taenia spp., Echinococcus; มักรวมในสูตรถ่ายพยาธิรวม (เช่น Drontal)",
      "cites": [
        "merck-anthelmintics"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ปลอดภัยสูง; ระวังในลูกสัตว์เล็กมากตามฉลากผลิตภัณฑ์",
      "cites": [
        "merck-anthelmintics"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "พบน้อย: อาเจียน ท้องเสีย เบื่ออาหาร เจ็บบริเวณที่ฉีด (รูปแบบฉีด)",
      "cites": [
        "merck-anthelmintics"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Tapeworm (cestode)",
      "route": "PO",
      "dose": "5 mg/kg PO ครั้งเดียว (อาจซ้ำตามชนิดพยาธิ)",
      "cites": [
        "merck-anthelmintics"
      ]
    },
    {
      "species": "feline",
      "indication": "Tapeworm (cestode)",
      "route": "PO",
      "dose": "5 mg/kg PO ครั้งเดียว",
      "cites": [
        "merck-anthelmintics"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-anthelmintics",
      "type": "textbook",
      "title": "Anthelmintics — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/anthelmintics/anthelmintics-introduction",
      "note": "Merck antiparasitic pharmacology — macrocyclic lactone / praziquantel / pyrantel dosing. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "dailymed-praziquantel",
      "type": "regulatory-database",
      "title": "Praziquantel — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=praziquantel",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "c9710620114dfb98632b8b429023cdd30266fb4ed4e5d76eab81639d62620b17"
    },
    {
      "id": "atc-P02BA01",
      "type": "guideline",
      "title": "ATC P02BA01 — Praziquantel",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=P02BA01&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "aec6811ba8c149f827529ef4be2b919d76c5ca45d2f1b6caf9d6409b55961dde"
    },
    {
      "id": "pubchem-praziquantel",
      "type": "monograph",
      "title": "Praziquantel — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Praziquantel",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "38428acd4e3f867f13e01f3c8478b582f92ded9f0deb0ce8b72dd7afad64a542"
    },
    {
      "id": "who-eml-22",
      "type": "guideline",
      "title": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "year": 2021,
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "note": "Cross-checked source: drug appears on WHO EML — WHO recognizes its place in basic healthcare.",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=praziquantel",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=P02BA01&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Praziquantel",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    },
    {
      "id": "who-eml",
      "name": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "asOfDate": "2026-05-27",
      "license": "CC BY-NC-SA 3.0 IGO"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "c9710620114dfb98632b8b429023cdd30266fb4ed4e5d76eab81639d62620b17",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "aec6811ba8c149f827529ef4be2b919d76c5ca45d2f1b6caf9d6409b55961dde",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "38428acd4e3f867f13e01f3c8478b582f92ded9f0deb0ce8b72dd7afad64a542",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "who-eml",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "P02BA01",
      "name": "Praziquantel",
      "level": 5
    },
    "rxnorm": {
      "cui": "8612",
      "name": "Praziquantel"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 4 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM), WHO Model List of Essential Medicines (22nd List, 2021)). ATC P02BA01 + RxNorm 8612. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — praziquantel 5 mg/kg verified against Merck anthelmintics. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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