Verify Posaconazole

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "posaconazole",
  "nameEn": "Posaconazole",
  "nameTh": "โพซาโคนาโซล",
  "class": "Triazole antifungal (extended-spectrum)",
  "mechanism": "ยับยั้ง 14α-demethylase ขัดขวางการสร้าง ergosterol ของเชื้อรา ครอบคลุมกว้างกว่ารุ่นเก่า รวมเชื้อราดื้อยาและ mucormycosis",
  "brandNamesTh": [
    "Noxafil"
  ],
  "indications": [
    {
      "text": "การติดเชื้อราในระบบที่ดื้อยา/รุนแรง (aspergillosis, cryptococcosis, mucormycosis, เชื้อราที่จมูกในสุนัข) ที่ไม่ตอบสนอง itraconazole/fluconazole",
      "cites": [
        "dailymed-posaconazole",
        "plumbs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ตับบกพร่อง (ติดตามเอนไซม์ตับ); ยับยั้ง CYP3A4 (drug interaction มาก); ราคาสูง — สงวนสำหรับเคสดื้อยา",
      "cites": [
        "dailymed-posaconazole",
        "plumbs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "อาเจียน/เบื่ออาหาร, เอนไซม์ตับขึ้น, drug interaction จากการยับยั้ง CYP",
      "cites": [
        "plumbs",
        "wikipedia-Posaconazole"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Resistant systemic mycosis",
      "route": "PO",
      "dose": "~5 mg/kg PO วันละครั้ง (พร้อมอาหารมัน) — ปรับตามเชื้อและการตอบสนอง",
      "cites": [
        "plumbs",
        "dailymed-posaconazole"
      ]
    },
    {
      "species": "feline",
      "indication": "Resistant systemic mycosis",
      "route": "PO",
      "dose": "~5 mg/kg PO วันละครั้ง พร้อมอาหาร",
      "cites": [
        "plumbs"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-J02AC04",
      "type": "regulatory-database",
      "title": "WHO ATC/DDD Index — Posaconazole (J02AC04)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=J02AC04&showdescription=no",
      "note": "WHO Anatomical Therapeutic Chemical classification. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "dailymed-posaconazole",
      "type": "package-insert",
      "title": "Posaconazole — DailyMed (US FDA label)",
      "year": 2026,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=posaconazole",
      "note": "US FDA structured product label. Authoritative for indications, contraindications, labeled use.",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Species doses cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "wikipedia-Posaconazole",
      "type": "monograph",
      "title": "Posaconazole — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Posaconazole",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "J02AC04",
      "name": "Posaconazole",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (WHO ATC / FDA label / Plumb’s / VSSO), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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