Verify Phenylbutazone

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "phenylbutazone",
  "nameEn": "Phenylbutazone",
  "nameTh": "ฟีนิลบิวทาโซน",
  "class": "NSAID — pyrazolone (equine musculoskeletal analgesic)",
  "mechanism": "ยับยั้ง COX ลดการสร้าง prostaglandin แก้ปวดและลดอักเสบของระบบกล้ามเนื้อ-กระดูก โดยเฉพาะในม้า (เรียกสั้น ๆ ว่า “bute”)",
  "brandNamesTh": [
    "Bute",
    "Equipalazone"
  ],
  "indications": [
    {
      "text": "อาการปวด/อักเสบของระบบกล้ามเนื้อ-กระดูก (lameness, osteoarthritis, laminitis) ในม้า",
      "cites": [
        "dailymed-phenylbutazone",
        "plumbs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ห้ามใช้ในสัตว์ที่ให้ผลผลิตเป็นอาหารคน (เนื้อ/นม) โดยเด็ดขาด; ห้ามในแผล GI, โรคไต/ตับ, ภาวะเลือดผิดปกติ (blood dyscrasia)",
      "cites": [
        "dailymed-phenylbutazone",
        "plumbs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "แผลในทางเดินอาหาร, พิษต่อไต, การกดไขกระดูก (blood dyscrasia โดยเฉพาะในสุนัข), แผลในช่องปาก",
      "cites": [
        "plumbs",
        "wikipedia-Phenylbutazone"
      ]
    }
  ],
  "dosages": [
    {
      "species": "equine",
      "indication": "Musculoskeletal pain / lameness",
      "route": "PO",
      "dose": "2.2–4.4 mg/kg PO/IV ทุก 12 ชั่วโมงในวันแรก แล้วลดเป็น 2.2–4.4 mg/kg วันละครั้ง; ใช้ขนาดต่ำสุดที่ได้ผล",
      "cites": [
        "plumbs",
        "dailymed-phenylbutazone"
      ]
    },
    {
      "species": "canine",
      "indication": "Inflammation / pain (off-label)",
      "route": "PO",
      "dose": "2.2–4.4 mg/kg PO ทุก 8–12 ชั่วโมง (สูงสุด ~800 mg/วัน) — off-label, ระวัง blood dyscrasia, มี NSAID สุนัขที่เหมาะกว่า",
      "cites": [
        "plumbs"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-M01AA01",
      "type": "regulatory-database",
      "title": "WHO ATC/DDD Index — Phenylbutazone (M01AA01)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=M01AA01&showdescription=no",
      "note": "WHO Anatomical Therapeutic Chemical (incl. ATCvet Q-codes) classification. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "dailymed-phenylbutazone",
      "type": "package-insert",
      "title": "Phenylbutazone — DailyMed (US FDA label)",
      "year": 2026,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=phenylbutazone",
      "note": "US FDA structured product label (human or veterinary). Authoritative for indications, contraindications, labeled dose.",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Species doses cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "wikipedia-Phenylbutazone",
      "type": "monograph",
      "title": "Phenylbutazone — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Phenylbutazone",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "M01AA01",
      "name": "Phenylbutazone",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (WHO ATC / FDA label / Plumb’s / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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