Verify Phenoxybenzamine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "phenoxybenzamine",
  "nameEn": "Phenoxybenzamine",
  "nameTh": "ฟีนอกซีเบนซามีน",
  "class": "Urinary — alpha-adrenergic antagonist (urethral relaxant)",
  "mechanism": "irreversible non-selective alpha-adrenergic blocker — คลายกล้ามเนื้อเรียบของหูรูดท่อปัสสาวะส่วนใน (internal urethral sphincter) และขยายหลอดเลือด; ออกฤทธิ์ยาว (จับ receptor ถาวร)",
  "brandNamesTh": [
    "Dibenzyline"
  ],
  "indications": [
    {
      "text": "คลายหูรูดท่อปัสสาวะใน functional urethral obstruction / reflex dyssynergia (internal sphincter tone สูง) ในสุนัขและแมว; เตรียมก่อนผ่าตัด pheochromocytoma (คุมความดัน)",
      "cites": [
        "merck-urine-retention-b",
        "petplace-phenoxybenzamine"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ออกฤทธิ์ช้า (อาจ 3–5 วันกว่าเห็นผลเต็มที่ — irreversible binding); ⚠️ hypotension + reflex tachycardia + คัดจมูก; ระวังในโรคหัวใจ/ไตวาย; titrate จากขนาดต่ำ",
      "cites": [
        "merck-urine-retention-b",
        "petplace-phenoxybenzamine"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ความดันต่ำ หัวใจเต้นเร็วสะท้อนกลับ อ่อนแรง เวียน คัดจมูก; ออกฤทธิ์นานหลังหยุดยา",
      "cites": [
        "petplace-phenoxybenzamine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Reflex dyssynergia / urethral relaxation",
      "route": "PO",
      "dose": "0.25–1 mg/kg PO ทุก 8–24 ชั่วโมง อย่างน้อย 5 วัน (หรือ 5–20 mg/ตัว วันละ 1–2 ครั้ง)",
      "cites": [
        "merck-urine-retention-b",
        "petplace-phenoxybenzamine"
      ]
    },
    {
      "species": "feline",
      "indication": "Functional urethral obstruction",
      "route": "PO",
      "dose": "2.5–7.5 mg/ตัว PO วันละ 1–2 ครั้ง",
      "cites": [
        "petplace-phenoxybenzamine"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-urine-retention-b",
      "type": "textbook",
      "title": "Pharmacotherapeutics in Urine Retention in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-urinary-system/pharmacotherapeutics-in-urine-retention-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "petplace-phenoxybenzamine",
      "type": "monograph",
      "title": "Phenoxybenzamine (Dibenzyline) for Dogs and Cats — PetPlace",
      "url": "https://www.petplace.com/article/drug-library/drug-library/library/phenoxybenzamine-dibenzyline-for-dogs-and-cats",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-phenoxybenzamine",
      "type": "monograph",
      "title": "Phenoxybenzamine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Phenoxybenzamine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "C04AX02",
      "name": "Phenoxybenzamine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VIN / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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