Verify Penicillin G (benzylpenicillin)

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "penicillin-g",
  "nameEn": "Penicillin G (benzylpenicillin)",
  "nameTh": "เพนิซิลลิน จี",
  "class": "Antibiotic — natural penicillin (beta-lactam)",
  "mechanism": "natural penicillin ยับยั้งการสร้างผนังเซลล์แบคทีเรีย (bind PBP); ออกฤทธิ์ดีต่อ gram-positive และ anaerobe หลายชนิด แต่ถูก beta-lactamase ทำลายและสเปกตรัมแคบกว่า aminopenicillin",
  "brandNamesTh": [
    "Penicillin G sodium/potassium",
    "Procaine penicillin G"
  ],
  "indications": [
    {
      "text": "ติดเชื้อ gram-positive และ anaerobe ที่ไวต่อยา (เช่น Clostridium, Streptococcus), leptospirosis, แผลติดเชื้อ; รูป procaine ออกฤทธิ์ยาวให้ IM",
      "cites": [
        "merck-penicillins-i",
        "vca-pengsodium"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามในสัตว์แพ้ penicillin/cephalosporin; ⚠️ procaine penicillin ห้ามให้ IV (procaine เป็นพิษ); ปรับในไตบกพร่อง; ไม่ครอบคลุมเชื้อที่สร้าง beta-lactamase",
      "cites": [
        "merck-penicillins-i"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "แพ้ยา (ผื่น anaphylaxis), GI upset, เปลี่ยน gut flora; procaine reaction (ตื่นเต้น/ชัก) ถ้าฉีดเข้าหลอดเลือดโดยไม่ตั้งใจ",
      "cites": [
        "vca-pengsodium"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Susceptible gram-positive / anaerobe",
      "route": "IV",
      "dose": "20,000–40,000 IU/kg IV/IM ทุก 6–8 ชั่วโมง (penicillin G sodium/potassium)",
      "cites": [
        "merck-penicillins-i",
        "vca-pengsodium"
      ]
    },
    {
      "species": "canine",
      "indication": "Sustained coverage (procaine)",
      "route": "IM",
      "dose": "20,000–40,000 IU/kg IM ทุก 12–24 ชั่วโมง (procaine penicillin G — IM เท่านั้น)",
      "cites": [
        "merck-penicillins-i"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-penicillins-i",
      "type": "textbook",
      "title": "Penicillins — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/antibacterial-agents/penicillins",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "vca-pengsodium",
      "type": "monograph",
      "title": "Penicillin G — drug reference",
      "url": "https://www.merckvetmanual.com/pharmacology/antibacterial-agents/penicillins",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-benzylpenicillin",
      "type": "monograph",
      "title": "Benzylpenicillin (penicillin G) — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Benzylpenicillin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "J01CE01",
      "name": "Benzylpenicillin (penicillin G)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / ACVIM-AAHA / VIN / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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