Verify Paroxetine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "paroxetine",
  "nameEn": "Paroxetine",
  "nameTh": "พารอกซีทีน",
  "class": "Behavioral / CNS — selective serotonin reuptake inhibitor (SSRI)",
  "mechanism": "SSRI ยับยั้งการเก็บกลับ serotonin เพิ่ม serotonergic tone; ใช้กับปัญหาพฤติกรรมเรื้อรัง มีฤทธิ์ anticholinergic มากกว่า SSRI อื่นเล็กน้อย — ออกฤทธิ์เต็มที่ 4–6 สัปดาห์",
  "brandNamesTh": [
    "Paxil",
    "Seroxat"
  ],
  "indications": [
    {
      "text": "ความวิตกกังวล, ความก้าวร้าวจากความกลัว, พฤติกรรมย้ำทำ และ urine marking ในสุนัขและแมว (ใช้คู่ behavior modification)",
      "cites": [
        "merck-behavior-i",
        "vca-paroxetine"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ห้ามใช้ร่วม MAOI/serotonergic (serotonin syndrome); ระวังฤทธิ์ anticholinergic (ปัสสาวะคั่ง ท้องผูก); หยุดยาค่อย ๆ ลด (discontinuation effect); ออกฤทธิ์ช้า",
      "cites": [
        "merck-behavior-i"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "เบื่ออาหาร, ท้องผูก/ปัสสาวะคั่ง (anticholinergic), ซึมหรือกระสับกระส่าย",
      "cites": [
        "vca-paroxetine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Anxiety / fear aggression",
      "route": "PO",
      "dose": "1–1.5 mg/kg PO วันละครั้ง",
      "cites": [
        "merck-behavior-i",
        "vca-paroxetine"
      ]
    },
    {
      "species": "feline",
      "indication": "Anxiety / urine marking",
      "route": "PO",
      "dose": "0.5–1 mg/kg (≈ 1.25–2.5 mg/ตัว) PO วันละครั้ง",
      "cites": [
        "vca-paroxetine"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-behavior-i",
      "type": "textbook",
      "title": "Behavioral Pharmacology — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/behavior/behavioral-medicine-introduction/drugs-and-behavior",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "vca-paroxetine",
      "type": "monograph",
      "title": "Paroxetine — VCA Animal Hospitals",
      "url": "https://vcahospitals.com/know-your-pet/paroxetine",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-paroxetine",
      "type": "monograph",
      "title": "Paroxetine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Paroxetine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "N06AB05",
      "name": "Paroxetine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / ACVIM-AAHA / VIN / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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