Verify Paromomycin

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "paromomycin",
  "nameEn": "Paromomycin",
  "nameTh": "พาโรโมมัยซิน",
  "class": "Intestinal — aminoglycoside antiprotozoal (oral, non-absorbed)",
  "mechanism": "aminoglycoside ที่ดูดซึมทางลำไส้น้อยมาก — ออกฤทธิ์เฉพาะที่ในลำไส้ ฆ่าโปรโตซัวและแบคทีเรีย; ใช้กับ cryptosporidiosis และ giardiasis",
  "brandNamesTh": [
    "Humatin",
    "Paromomycin"
  ],
  "indications": [
    {
      "text": "cryptosporidiosis และ giardiasis ในแมว (และสุนัข) — โดยเฉพาะเมื่อ metronidazole/fenbendazole ไม่ได้ผล",
      "cites": [
        "paper-paromomycin",
        "merck-giardia"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ แม้ดูดซึมน้อย แต่ในลำไส้ที่อักเสบ/เป็นแผล ดูดซึมเพิ่ม → เคยมีรายงาน acute renal failure + หูหนวก (ototoxicity/nephrotoxicity) ในแมว — ใช้ระวังมาก เลี่ยงในลำไส้อักเสบ; ห้ามในไตบกพร่อง",
      "cites": [
        "paper-paromomycin"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "⚠️ nephrotoxicity + ototoxicity (หูหนวก) เมื่อดูดซึม (โดยเฉพาะลำไส้อักเสบในแมว); GI upset",
      "cites": [
        "paper-paromomycin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "feline",
      "indication": "Cryptosporidiosis",
      "route": "PO",
      "dose": "125–165 mg/kg PO วันละครั้ง นาน 5 วัน — ⚠️ เฝ้าระวังไต/การได้ยิน, เลี่ยงในลำไส้อักเสบ",
      "cites": [
        "paper-paromomycin",
        "merck-giardia"
      ]
    },
    {
      "species": "feline",
      "indication": "Giardiasis",
      "route": "PO",
      "dose": "25–75 mg/kg PO วันละครั้ง นาน 5 วัน",
      "cites": [
        "merck-giardia"
      ]
    }
  ],
  "citations": [
    {
      "id": "paper-paromomycin",
      "type": "paper",
      "title": "Use of paromomycin for treatment of cryptosporidiosis in a cat (incl. renal/ototoxicity caution)",
      "url": "https://pubmed.ncbi.nlm.nih.gov/7744647/",
      "year": 2023,
      "note": "Peer-reviewed feline paromomycin case + toxicity report.",
      "cid": null
    },
    {
      "id": "merck-giardia",
      "type": "textbook",
      "title": "Giardiasis in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/digestive-system/giardiasis-giardia/giardiasis-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-paromomycin",
      "type": "monograph",
      "title": "Paromomycin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Paromomycin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "A07AA06",
      "name": "Paromomycin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VCA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

[]