Verify Omeprazole

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "omeprazole",
  "nameEn": "Omeprazole",
  "nameTh": "โอเมพราโซล",
  "class": "Proton pump inhibitor — irreversible H+/K+-ATPase block",
  "mechanism": "ยับยั้งปั๊มโปรตอน H+/K+-ATPase ที่ parietal cell อย่างถาวร จึงลดการหลั่งกรดได้แรงและนาน (ออกฤทธิ์คุมกรด 3–4 วันจากโดสเดียวในสุนัข แม้ครึ่งชีวิตในเลือดสั้น); เหนือกว่า H2 blocker ในการรักษาแผลในทางเดินอาหาร",
  "brandNamesTh": [
    "Prilosec",
    "Losec",
    "GastroGard"
  ],
  "indications": [
    {
      "text": "แผลและการสึกกร่อนในทางเดินอาหาร (GUE), gastritis, reflux esophagitis; เป็นยาเลือกแรกกลุ่มลดกรดตาม ACVIM consensus",
      "cites": [
        "acvim-gi-protectant"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "หลีกเลี่ยงการหยุดยากะทันหันหลังใช้นาน (rebound acid hypersecretion ควรค่อย ๆ ลด); แยกเวลาจาก sucralfate อย่างน้อย 2 ชั่วโมง",
      "cites": [
        "acvim-gi-protectant"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "โดยรวมปลอดภัย; ใช้นานอาจกระทบการดูดซึมสารอาหารและ microbiome; rebound hyperacidity เมื่อหยุดกะทันหัน",
      "cites": [
        "acvim-gi-protectant"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "GI ulcer / erosion / reflux",
      "route": "PO",
      "dose": "0.5–1 mg/kg PO ทุก 12–24 ชั่วโมง (แนะนำให้วันละ 2 ครั้งเพื่อคุม pH ได้ดีกว่า)",
      "cites": [
        "acvim-gi-protectant",
        "merck-antiulcer"
      ]
    },
    {
      "species": "feline",
      "indication": "GI ulcer / erosion",
      "route": "PO",
      "dose": "0.5–1 mg/kg PO ทุก 12–24 ชั่วโมง",
      "cites": [
        "acvim-gi-protectant"
      ]
    }
  ],
  "citations": [
    {
      "id": "acvim-gi-protectant",
      "type": "guideline",
      "title": "ACVIM Consensus Statement: Rational administration of gastrointestinal protectants to dogs and cats",
      "authors": "Marks SL, et al.",
      "year": 2018,
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6271318/",
      "note": "Peer-reviewed ACVIM consensus (J Vet Intern Med) — PPI/H2/sucralfate evidence + dosing. Authoritative.",
      "cid": null
    },
    {
      "id": "merck-antiulcer",
      "type": "textbook",
      "title": "Antiulcerative Drugs — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/multimedia/table/antiulcerative-drugs",
      "note": "Merck antiulcerative dosing table. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "dailymed-omeprazole",
      "type": "regulatory-database",
      "title": "Omeprazole — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=omeprazole",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "a961fd104b2f2e78f17e528dcb15b5b5022848323cd1c7266b557e04540bb0d8"
    },
    {
      "id": "atc-A02BC01",
      "type": "guideline",
      "title": "ATC A02BC01 — Omeprazole",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=A02BC01&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "72a25050f86e353b2574b32b0449bdeefe439fc71a8deb079fd515fda7a214fb"
    },
    {
      "id": "pubchem-omeprazole",
      "type": "monograph",
      "title": "Omeprazole — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Omeprazole",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "c52d92669fbcbf34fecb8de60bf7547f65b469e48a4e0f5bf747b1a98a3c9b3c"
    },
    {
      "id": "who-eml-22",
      "type": "guideline",
      "title": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "year": 2021,
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "note": "Cross-checked source: drug appears on WHO EML — WHO recognizes its place in basic healthcare.",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=omeprazole",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=A02BC01&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Omeprazole",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    },
    {
      "id": "who-eml",
      "name": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "asOfDate": "2026-05-27",
      "license": "CC BY-NC-SA 3.0 IGO"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "a961fd104b2f2e78f17e528dcb15b5b5022848323cd1c7266b557e04540bb0d8",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "72a25050f86e353b2574b32b0449bdeefe439fc71a8deb079fd515fda7a214fb",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "c52d92669fbcbf34fecb8de60bf7547f65b469e48a4e0f5bf747b1a98a3c9b3c",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "who-eml",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "A02BC01",
      "name": "Omeprazole",
      "level": 5
    },
    "rxnorm": {
      "cui": "7646",
      "name": "Omeprazole"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 4 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM), WHO Model List of Essential Medicines (22nd List, 2021)). ATC A02BC01 + RxNorm 7646. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — omeprazole 0.5–1 mg/kg PO q12–24h (BID preferred) verified against ACVIM consensus + Merck antiulcerative table. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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