Verify Octreotide

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "octreotide",
  "nameEn": "Octreotide",
  "nameTh": "อ็อกทรีโอไทด์",
  "class": "Pituitary hormones — somatostatin analogue",
  "mechanism": "somatostatin analogue ออกฤทธิ์ยาว — ยับยั้งการสร้างและหลั่ง insulin จาก beta cell (และฮอร์โมนอื่นหลายชนิด) จึงลดภาวะน้ำตาลต่ำใน insulinoma",
  "brandNamesTh": [
    "Sandostatin"
  ],
  "indications": [
    {
      "text": "คุมภาวะน้ำตาลต่ำจาก insulinoma (เนื้องอก beta cell) ในสุนัข — เป็นทางเลือกเสริม/ทดแทนเมื่อ diet+prednisolone+diazoxide ไม่พอ; ตอบสนองผันแปร (~50%)",
      "cites": [
        "paper-octreotide",
        "tvp-insulinoma"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "การตอบสนองผันแปรและมักอยู่ได้สั้นในสุนัข (ขึ้นกับ receptor subtype ของเนื้องอก); ราคาสูง; ต้องฉีด SC วันละหลายครั้ง; ไม่ใช่การรักษาหลัก (ผ่าตัดคือทางเลือกแรกถ้าทำได้)",
      "cites": [
        "paper-octreotide"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "โดยรวมปลอดภัย ไม่พบผลข้างเคียงชัดในการศึกษาสุนัข; GI upset ได้บ้าง",
      "cites": [
        "paper-octreotide"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Insulinoma hypoglycemia",
      "route": "SC",
      "dose": "10–40 mcg/ตัว SC ทุก 8–12 ชั่วโมง",
      "cites": [
        "paper-octreotide",
        "tvp-insulinoma"
      ]
    }
  ],
  "citations": [
    {
      "id": "paper-octreotide",
      "type": "paper",
      "title": "Evaluation of long-acting octreotide in management of insulinoma in three dogs (Simpson, JSAP 1995)",
      "url": "https://pubmed.ncbi.nlm.nih.gov/7603057/",
      "year": 2023,
      "note": "Peer-reviewed canine octreotide insulinoma study.",
      "cid": null
    },
    {
      "id": "tvp-insulinoma",
      "type": "guideline",
      "title": "Canine Insulinoma: Diagnosis, Treatment, Staging — Today's Veterinary Practice",
      "url": "https://todaysveterinarypractice.com/oncology/canine-insulinoma-diagnosis-treatment-staging/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-octreotide",
      "type": "monograph",
      "title": "Octreotide — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Octreotide",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "H01CB02",
      "name": "Octreotide",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / ACVIM / VCA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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