Verify Mupirocin (topical)

Drug JSON

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{
  "slug": "mupirocin",
  "nameEn": "Mupirocin (topical)",
  "nameTh": "มิวพิโรซิน (ทาภายนอก)",
  "class": "Antiseptic — topical antibiotic (pseudomonic acid)",
  "mechanism": "topical antibiotic (pseudomonic acid A) — ยับยั้ง bacterial isoleucyl-tRNA synthetase หยุดการสร้างโปรตีน; ออกฤทธิ์ดีต่อ gram-positive โดยเฉพาะ Staphylococcus (รวม MRSP/MRSA)",
  "brandNamesTh": [
    "Muricin",
    "Bactroban"
  ],
  "indications": [
    {
      "text": "ติดเชื้อแบคทีเรียที่ผิวหนังเฉพาะที่ (localized/superficial pyoderma) จาก Staphylococcus รวมสายพันธุ์ดื้อ methicillin, acne ในแมว (off-label) ในสุนัขและแมว",
      "cites": [
        "vca-mupirocin",
        "merck-integ-abx"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ใช้เฉพาะที่ ≤30 วัน; ⚠️ ฐานยา polyethylene glycol — เลี่ยงทาบริเวณกว้าง/แผลเปิดลึกในเคสที่ดูดซึม PEG ได้ (พิษไตทางทฤษฎี); ห้ามให้เลียออก 20–30 นาที; ต้อง contact time ~10 นาที",
      "cites": [
        "vca-mupirocin"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ระคายเฉพาะที่ (พบน้อย); ดูดซึม systemic น้อยมากเมื่อใช้บริเวณจำกัด",
      "cites": [
        "vca-mupirocin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Localized superficial pyoderma",
      "route": "topical",
      "dose": "ทา ointment 2% บริเวณรอยโรค วันละ 2 ครั้ง (ไม่เกิน 30 วัน); contact time ~10 นาที",
      "cites": [
        "vca-mupirocin",
        "merck-integ-abx"
      ]
    },
    {
      "species": "feline",
      "indication": "Chin acne / localized pyoderma (off-label)",
      "route": "topical",
      "dose": "ทา ointment 2% บาง ๆ วันละ 2 ครั้ง",
      "cites": [
        "vca-mupirocin"
      ]
    }
  ],
  "citations": [
    {
      "id": "vca-mupirocin",
      "type": "monograph",
      "title": "Mupirocin Topical — VCA Animal Hospitals",
      "url": "https://vcahospitals.com/know-your-pet/mupirocin-topical",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "merck-integ-abx",
      "type": "textbook",
      "title": "Antibacterials for Integumentary Disease in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-integumentary-system/antibacterials-for-integumentary-disease-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-mupirocin",
      "type": "monograph",
      "title": "Mupirocin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Mupirocin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "D06AX09",
      "name": "Mupirocin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VCA / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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