Verify Moxidectin

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "moxidectin",
  "nameEn": "Moxidectin",
  "nameTh": "มอกซิเดกติน",
  "class": "Antiparasitic — macrocyclic lactone (milbemycin)",
  "mechanism": "macrocyclic lactone กลุ่ม milbemycin จับ glutamate-gated chloride channel ของพยาธิ ทำให้เป็นอัมพาตและตาย; ใช้ป้องกันพยาธิหนอนหัวใจและกำจัดพยาธิภายใน/ภายนอก มีรูปฉีดออกฤทธิ์ยาว (ProHeart)",
  "brandNamesTh": [
    "ProHeart",
    "Advocate/Advantage Multi (คู่ imidacloprid)"
  ],
  "indications": [
    {
      "text": "ป้องกันพยาธิหนอนหัวใจ (Dirofilaria immitis) ในสุนัข/แมว, กำจัดพยาธิตัวกลมในลำไส้, ไรขี้เรื้อน (demodicosis/sarcoptic ในสูตรเฉพาะ); รูปฉีด ProHeart ป้องกันได้ 6–12 เดือน",
      "cites": [
        "tvp-moxidectin",
        "paper-moxidectin"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวังในสุนัขพันธุ์ที่มี MDR1/ABCB1 mutation (Collie ฯลฯ) — ไวต่อ neurotoxicity ที่ขนาดสูง; ตรวจ heartworm antigen ก่อนเริ่มป้องกัน; รูปฉีดให้โดยสัตวแพทย์เท่านั้น",
      "cites": [
        "tvp-moxidectin"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "โดยทั่วไปปลอดภัยที่ขนาดป้องกัน; ขนาดสูง/MDR1 → ataxia ซึม น้ำลายไหล ชัก; ปฏิกิริยาบริเวณฉีด (รูป depot)",
      "cites": [
        "tvp-moxidectin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Heartworm prevention (oral monthly)",
      "route": "PO",
      "dose": "24 µg/kg PO เดือนละครั้ง (สูตรกินรุ่นใหม่; สูตรเดิม 3 µg/kg)",
      "cites": [
        "paper-moxidectin"
      ]
    },
    {
      "species": "canine",
      "indication": "Heartworm prevention (extended-release injection)",
      "route": "SC",
      "dose": "ProHeart 6: 0.17 mg/kg SC ทุก 6 เดือน; ProHeart 12: 0.5 mg/kg SC ทุก 12 เดือน — สัตวแพทย์ให้",
      "cites": [
        "tvp-moxidectin",
        "paper-moxidectin"
      ]
    }
  ],
  "citations": [
    {
      "id": "tvp-moxidectin",
      "type": "guideline",
      "title": "Moxidectin for Dogs — Today's Veterinary Practice",
      "url": "https://todaysveterinarypractice.com/pharmacology/moxidectin-for-dogs/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "paper-moxidectin",
      "type": "paper",
      "title": "Preventive efficacy of oral moxidectin at various doses against heartworm in dogs (Parasites & Vectors)",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6737633/",
      "year": 2023,
      "note": "Peer-reviewed canine moxidectin heartworm-prevention study.",
      "cid": null
    },
    {
      "id": "wikipedia-moxidectin",
      "type": "monograph",
      "title": "Moxidectin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Moxidectin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "QP54AA02",
      "name": "Moxidectin",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / ACVIM-AAHA / VIN / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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