Verify Mitoxantrone

Drug JSON

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{
  "slug": "mitoxantrone",
  "nameEn": "Mitoxantrone",
  "nameTh": "ไมทอกแซนโทรน",
  "class": "Antineoplastic — anthracenedione (topoisomerase II inhibitor)",
  "mechanism": "anthracenedione แทรกตัวใน DNA และยับยั้ง topoisomerase II ขัดขวางการจำลอง/ซ่อม DNA; cardiotoxic น้อยกว่า doxorubicin จึงใช้แทนในบางโปรโตคอล",
  "brandNamesTh": [
    "Novantrone"
  ],
  "indications": [
    {
      "text": "lymphoma, transitional cell carcinoma (TCC, คู่ piroxicam), squamous cell carcinoma และมะเร็งอื่น ในสุนัขและแมว — เป็น rescue/substitute ของ doxorubicin",
      "cites": [
        "vsso-mitoxantrone",
        "paper-mitox"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ยาเคมีบำบัด PPE; กดไขกระดูก (neutropenia nadir); ⚠️ ทำให้ปัสสาวะ/ตาขาว/น้ำตาเป็นสีฟ้า-เขียว (คาดได้); ปรับในตับบกพร่อง; เจือจางใน NaCl 0.9% ก่อนให้ IV",
      "cites": [
        "vsso-mitoxantrone",
        "paper-mitox"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดไขกระดูก (neutropenia), GI (อาเจียน เบื่ออาหาร ท้องเสีย), ปัสสาวะสีฟ้า-เขียว; cardiotoxicity น้อยกว่า doxorubicin",
      "cites": [
        "paper-mitox"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Lymphoma / carcinoma — specialist",
      "route": "IV",
      "dose": "5–6 mg/m² IV ทุก 21 วัน (TCC ใช้ 5–5.5 mg/m² คู่ piroxicam) — ⚠️ oncology only, เจือจางใน NaCl",
      "notes": "ตรวจ CBC ก่อนทุกรอบ",
      "cites": [
        "vsso-mitoxantrone",
        "paper-mitox"
      ]
    },
    {
      "species": "feline",
      "indication": "Lymphoma / carcinoma — specialist",
      "route": "IV",
      "dose": "5.5–6.5 mg/m² IV ทุก 21 วัน — ⚠️ oncology only",
      "cites": [
        "vsso-mitoxantrone"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ CBC ก่อนทุกรอบ (neutrophil nadir); ค่าตับ; เฝ้าระวังหัวใจเมื่อใช้สะสม",
      "cites": [
        "vsso-mitoxantrone"
      ]
    }
  ],
  "citations": [
    {
      "id": "vsso-mitoxantrone",
      "type": "guideline",
      "title": "Mitoxantrone chemotherapy protocol — Veterinary Society of Surgical Oncology",
      "url": "https://www.vsso.org/chemotherapy-protocols",
      "year": 2024,
      "note": "VSSO chemotherapy protocol reference.",
      "cid": null
    },
    {
      "id": "paper-mitox",
      "type": "paper",
      "title": "Efficacy of mitoxantrone against various neoplasms in dogs",
      "url": "https://pubmed.ncbi.nlm.nih.gov/2061177/",
      "year": 2023,
      "note": "Peer-reviewed canine mitoxantrone efficacy study.",
      "cid": null
    },
    {
      "id": "wikipedia-mitoxantrone",
      "type": "monograph",
      "title": "Mitoxantrone — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Mitoxantrone",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "L01DB07",
      "name": "Mitoxantrone",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / EMA-FDA labels / VSSO / ACVIM-AAHA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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