Verify Milbemycin oxime

Drug JSON

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{
  "slug": "milbemycin-oxime",
  "nameEn": "Milbemycin oxime",
  "nameTh": "มิลบีมัยซิน ออกซิม",
  "class": "Antiparasitic — macrocyclic lactone (heartworm + intestinal)",
  "mechanism": "macrocyclic lactone ออกฤทธิ์ที่ glutamate-gated chloride channel ของปรสิต ทำให้อัมพาตและตาย; ใช้ป้องกันพยาธิหนอนหัวใจและกำจัดพยาธิในลำไส้",
  "brandNamesTh": [
    "Interceptor",
    "Milbemax",
    "Sentinel"
  ],
  "indications": [
    {
      "text": "ป้องกันพยาธิหนอนหัวใจรายเดือน และกำจัดพยาธิตัวกลม ปากขอ แส้ม้า ในสุนัขและแมว; ใช้ขนาดสูงในการรักษา demodicosis บางโปรโตคอล",
      "cites": [
        "merck-milbemycin"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ตรวจว่าไม่มีพยาธิหนอนหัวใจก่อนเริ่ม (heartworm test); ปลอดภัยกว่า ivermectin ในสุนัข MDR1 ที่ขนาดป้องกัน แต่ขนาดสูงยังต้องระวัง",
      "cites": [
        "merck-milbemycin"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "พบน้อยที่ขนาดป้องกัน; ในสุนัขที่มี microfilaria จำนวนมากอาจเกิดปฏิกิริยาจากพยาธิตาย",
      "cites": [
        "merck-milbemycin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Heartworm prevention / intestinal nematodes",
      "route": "PO",
      "dose": "0.5 mg/kg PO ทุกเดือน (ป้องกัน); ขนาดสูงกว่าในโปรโตคอลรักษา demodicosis",
      "cites": [
        "merck-milbemycin"
      ]
    },
    {
      "species": "feline",
      "indication": "Heartworm / intestinal nematodes",
      "route": "PO",
      "dose": "2 mg/kg PO ทุกเดือน",
      "cites": [
        "merck-milbemycin"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-milbemycin",
      "type": "textbook",
      "title": "Anthelmintics (Macrocyclic Lactones) — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/anthelmintics/macrocyclic-lactones",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-Milbemycin_oxime",
      "type": "monograph",
      "title": "Milbemycin oxime — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Milbemycin_oxime",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "QP54AA06",
      "name": "Milbemycin oxime",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / peer-reviewed studies), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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