Verify Midazolam

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "midazolam",
  "nameEn": "Midazolam",
  "nameTh": "ไมดาโซแลม",
  "class": "Sedative — short-acting benzodiazepine (water-soluble)",
  "mechanism": "ยากลุ่ม benzodiazepine ออกฤทธิ์สั้น ละลายน้ำได้ดี เสริมการทำงาน GABA-A; ให้ความสงบ คลายกล้ามเนื้อ และกันชัก; ใช้ร่วม ketamine/opioid เพื่อ co-induction",
  "brandNamesTh": [
    "Versed",
    "Dormicum"
  ],
  "indications": [
    {
      "text": "co-induction ร่วมกับ ketamine หรือ opioid, premedication, และควบคุมชัก; เนื่องจากละลายน้ำจึงดูดซึมดีเมื่อให้ IM (ต่างจาก diazepam)",
      "cites": [
        "lumb-jones-anesthesia"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวังในสัตว์ที่ตับบกพร่องรุนแรง; ให้เดี่ยวในสัตว์สุขภาพดีอาจเกิด paradoxical excitement",
      "cites": [
        "lumb-jones-anesthesia"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดการหายใจเมื่อใช้ร่วมยากดประสาทอื่น, ง่วงซึม, บางครั้ง paradoxical excitement; ใช้ extra-label ในสัตว์",
      "cites": [
        "lumb-jones-anesthesia"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Co-induction / premedication / seizure",
      "route": "IV",
      "dose": "0.2–0.4 mg/kg IV หรือ IM",
      "notes": "ใช้ extra-label — ตรวจสอบ protocol และให้ faculty ยืนยัน",
      "cites": [
        "lumb-jones-anesthesia"
      ]
    },
    {
      "species": "feline",
      "indication": "Co-induction / premedication",
      "route": "IV",
      "dose": "0.2–0.4 mg/kg IV หรือ IM",
      "cites": [
        "lumb-jones-anesthesia"
      ]
    }
  ],
  "citations": [
    {
      "id": "lumb-jones-anesthesia",
      "type": "textbook",
      "title": "Lumb & Jones Veterinary Anesthesia and Analgesia (5th ed.) — injectable agents",
      "year": 2015,
      "url": "https://veteriankey.com/anesthesia-management-of-dogs-and-cats/",
      "note": "Standard veterinary anesthesia reference for injectable-agent dosing (incl. extra-label benzodiazepine + phenothiazine use). Cited, not mirrored.",
      "cid": null
    },
    {
      "id": "dailymed-midazolam",
      "type": "regulatory-database",
      "title": "Midazolam — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=midazolam",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "fa15c0e5e45f200bb4147f1989347f84edf6e821db420b2e0ac92e20a96382db"
    },
    {
      "id": "atc-N05CD08",
      "type": "guideline",
      "title": "ATC N05CD08 — Midazolam",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=N05CD08&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "04215c70db345a716a73a127fb144d9467027e31dc773770914108cb7d1df2f8"
    },
    {
      "id": "pubchem-midazolam",
      "type": "monograph",
      "title": "Midazolam — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Midazolam",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "c84f339a7db14feb6a63c7e5d86f39fabac698e448acb548bec0ef5ded1d3133"
    },
    {
      "id": "who-eml-22",
      "type": "guideline",
      "title": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "year": 2021,
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "note": "Cross-checked source: drug appears on WHO EML — WHO recognizes its place in basic healthcare.",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb"
    },
    {
      "id": "wsava-anesth-2018",
      "type": "guideline",
      "title": "WSAVA Anaesthesia and Sedation Guidelines",
      "year": 2018,
      "url": "https://wsava.org/global-guidelines/",
      "note": "Cross-checked source: WSAVA framework for safe anesthesia + sedation protocols in companion animals.",
      "cid": "33d00d5e60cef25ef915e1a10bce437a52b208e15173796168c8d8868a2f1090"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=midazolam",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=N05CD08&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Midazolam",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    },
    {
      "id": "who-eml",
      "name": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "asOfDate": "2026-05-27",
      "license": "CC BY-NC-SA 3.0 IGO"
    },
    {
      "id": "wsava-anesth",
      "name": "WSAVA Anaesthesia & Sedation guidelines",
      "url": "https://wsava.org/global-guidelines/",
      "asOfDate": "2026-05-27",
      "license": "Free for educational use with attribution"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "fa15c0e5e45f200bb4147f1989347f84edf6e821db420b2e0ac92e20a96382db",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "04215c70db345a716a73a127fb144d9467027e31dc773770914108cb7d1df2f8",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "c84f339a7db14feb6a63c7e5d86f39fabac698e448acb548bec0ef5ded1d3133",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "who-eml",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "wsava-anesth",
      "cid": "33d00d5e60cef25ef915e1a10bce437a52b208e15173796168c8d8868a2f1090",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "N05CD08",
      "name": "Midazolam",
      "level": 5
    },
    "rxnorm": {
      "cui": "6960",
      "name": "Midazolam"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 5 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM), WHO Model List of Essential Medicines (22nd List, 2021), WSAVA Anaesthesia & Sedation guidelines). ATC N05CD08 + RxNorm 6960. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — midazolam 0.2–0.4 mg/kg IV/IM (extra-label) verified against Lumb & Jones. Flagged extra-label for faculty confirmation. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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