Verify Miconazole (topical)

Drug JSON

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{
  "slug": "miconazole",
  "nameEn": "Miconazole (topical)",
  "nameTh": "ไมโคนาโซล (ทาภายนอก)",
  "class": "Antifungal — imidazole (topical)",
  "mechanism": "imidazole antifungal — ยับยั้ง fungal CYP450 (14α-demethylase) ลดการสร้าง ergosterol ที่เยื่อหุ้มเซลล์เชื้อรา; รูปทาภายนอกใช้กับเชื้อราผิวหนังและ Malassezia",
  "brandNamesTh": [
    "Conofite",
    "Miconazole 2%",
    "Malaseb (คู่ chlorhexidine)"
  ],
  "indications": [
    {
      "text": "เชื้อราผิวหนัง (dermatophytosis/ringworm) และ Malassezia dermatitis ในสุนัขและแมว — รูปทา/แชมพู (มักผสม chlorhexidine เสริมฤทธิ์)",
      "cites": [
        "vca-miconazole",
        "merck-integ-antifungal"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ใช้ภายนอกเท่านั้น; ระคายผิว/แพ้สัมผัสบางตัว; เลี่ยงเข้าตา; สำหรับรอยโรคกว้าง/refractory พิจารณา systemic antifungal ร่วม",
      "cites": [
        "vca-miconazole"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ระคายผิว/แดงเฉพาะที่, แพ้สัมผัส (พบน้อย); ดูดซึม systemic น้อยมาก",
      "cites": [
        "vca-miconazole"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Dermatophytosis / Malassezia dermatitis",
      "route": "topical",
      "dose": "ทา lotion/cream 2% บาง ๆ บริเวณรอยโรค วันละครั้ง นาน 2–4 สัปดาห์; แชมพูตามคำแนะนำ",
      "cites": [
        "vca-miconazole",
        "merck-integ-antifungal"
      ]
    },
    {
      "species": "feline",
      "indication": "Dermatophytosis / Malassezia dermatitis",
      "route": "topical",
      "dose": "ทา 2% บาง ๆ วันละครั้ง; แชมพู (มักคู่ chlorhexidine)",
      "cites": [
        "vca-miconazole"
      ]
    }
  ],
  "citations": [
    {
      "id": "vca-miconazole",
      "type": "monograph",
      "title": "Miconazole Topical — VCA Animal Hospitals",
      "url": "https://vcahospitals.com/know-your-pet/miconazole-topical",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "merck-integ-antifungal",
      "type": "textbook",
      "title": "Antifungals for Integumentary Disease in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-integumentary-system/antifungals-for-integumentary-disease-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-miconazole",
      "type": "monograph",
      "title": "Miconazole — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Miconazole",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "D01AC02",
      "name": "Miconazole",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VCA / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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