Verify Mexiletine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "mexiletine",
  "nameEn": "Mexiletine",
  "nameTh": "เมกซิเลทีน",
  "class": "Cardiovascular — class Ib antiarrhythmic (oral)",
  "mechanism": "class Ib antiarrhythmic — ปิดกั้น fast sodium channel (คล้าย lidocaine แบบกินได้) ลด ventricular ectopy; มักใช้คู่ sotalol เสริมฤทธิ์",
  "brandNamesTh": [
    "Mexitil"
  ],
  "indications": [
    {
      "text": "ventricular arrhythmia เรื้อรัง (premature ventricular complex, ventricular tachycardia) ในสุนัข — รูปกินต่อยอดจาก lidocaine IV; คู่ sotalol คุม inherited VT (เช่น German Shepherd) ได้ดี",
      "cites": [
        "merck-antiarrhythmic-q2",
        "paper-mexiletine"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "GI upset เป็นผลข้างเคียงหลัก (ให้พร้อมอาหารช่วยลด); ระวังในตับบกพร่อง (เมแทบอลิซึมที่ตับ); ครึ่งชีวิตสั้นต้องให้บ่อย; ระวัง proarrhythmia",
      "cites": [
        "merck-antiarrhythmic-q2"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "GI upset (อาเจียน เบื่ออาหาร — dose-related), ตัวสั่น, ซึม; proarrhythmia พบน้อย",
      "cites": [
        "paper-mexiletine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Ventricular arrhythmia (chronic oral)",
      "route": "PO",
      "dose": "4–8 mg/kg PO ทุก 8 ชั่วโมง พร้อมอาหาร (ลด GI upset)",
      "cites": [
        "merck-antiarrhythmic-q2",
        "paper-mexiletine"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-antiarrhythmic-q2",
      "type": "textbook",
      "title": "Antiarrhythmics for Use in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-cardiovascular-system/antiarrhythmics-for-use-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "paper-mexiletine",
      "type": "paper",
      "title": "Mexiletine + sotalol for inherited ventricular arrhythmias in German Shepherds (randomized cross-over)",
      "url": "https://pubmed.ncbi.nlm.nih.gov/20663731/",
      "year": 2023,
      "note": "Peer-reviewed canine mexiletine study.",
      "cid": null
    },
    {
      "id": "wikipedia-mexiletine",
      "type": "monograph",
      "title": "Mexiletine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Mexiletine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "C01BB02",
      "name": "Mexiletine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / Tufts CardioRush / FDA labels / VCA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

[]