Verify Metoprolol

Drug JSON

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{
  "slug": "metoprolol",
  "nameEn": "Metoprolol",
  "nameTh": "เมโทโพรลอล",
  "class": "Cardiovascular — selective beta-1 blocker",
  "mechanism": "selective beta-1 adrenergic antagonist — ลดอัตราและแรงบีบหัวใจ ความต้องการออกซิเจนของกล้ามเนื้อหัวใจ และคุมการเต้นผิดจังหวะ; เลือก beta-1 จึงปลอดภัยกว่า propranolol ในโรคทางเดินหายใจ",
  "brandNamesTh": [
    "Lopressor",
    "Betaloc"
  ],
  "indications": [
    {
      "text": "หัวใจเต้นเร็ว/ผิดจังหวะ (supraventricular tachycardia), คุมอัตราหัวใจใน cardiomyopathy บางชนิด, ความดันสูง ในสุนัขและแมว — beta-1 selective (ดีกว่า propranolol เมื่อมีโรคหลอดลม)",
      "cites": [
        "merck-antiarrhythmic-t",
        "tufts-metoprolol-t"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ห้าม/ระวังในหัวใจล้มเหลวที่ยังไม่คุม, bradycardia/AV block; ห้ามหยุดกะทันหัน (rebound tachycardia/hypertension); ระวังในเบาหวาน (บัง hypoglycemia); selectivity ลดลงที่ขนาดสูง (ระวังหลอดลมหด)",
      "cites": [
        "merck-antiarrhythmic-t",
        "tufts-metoprolol-t"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "หัวใจเต้นช้า ความดันต่ำ ซึม/อ่อนแรง, แย่ลงใน CHF ที่ไม่คุม; หลอดลมหดที่ขนาดสูง",
      "cites": [
        "tufts-metoprolol-t"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Tachyarrhythmia / rate control",
      "route": "PO",
      "dose": "0.5–1 mg/kg PO ทุก 8–12 ชั่วโมง (เริ่มต่ำ titrate)",
      "cites": [
        "merck-antiarrhythmic-t",
        "tufts-metoprolol-t"
      ]
    },
    {
      "species": "feline",
      "indication": "Tachyarrhythmia (HCM adjunct)",
      "route": "PO",
      "dose": "2–15 mg/ตัว PO ทุก 8 ชั่วโมง (titrate)",
      "cites": [
        "tufts-metoprolol-t"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-antiarrhythmic-t",
      "type": "textbook",
      "title": "Antiarrhythmics for Use in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-cardiovascular-system/antiarrhythmics-for-use-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "tufts-metoprolol-t",
      "type": "guideline",
      "title": "Metoprolol — Tufts CardioRush Cardiology Drug Formulary",
      "url": "https://sites.tufts.edu/cardiorush/cardiology-drug-formulary/",
      "year": 2024,
      "note": "Tufts cardiology reference dosing.",
      "cid": null
    },
    {
      "id": "wikipedia-metoprolol",
      "type": "monograph",
      "title": "Metoprolol — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Metoprolol",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "C07AB02",
      "name": "Metoprolol",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / Tufts CardioRush / VCA / dvm360 / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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