Verify Methylprednisolone

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "methylprednisolone",
  "nameEn": "Methylprednisolone",
  "nameTh": "เมทิลเพรดนิโซโลน",
  "class": "Corticosteroid — intermediate-acting glucocorticoid",
  "mechanism": "glucocorticoid สังเคราะห์ออกฤทธิ์ปานกลาง ความแรงสูงกว่า prednisolone เล็กน้อย มีฤทธิ์ mineralocorticoid ต่ำกว่า; รูปแบบ Depo-Medrol เป็น depot ออกฤทธิ์ยาว",
  "brandNamesTh": [
    "Medrol",
    "Depo-Medrol",
    "Solu-Medrol"
  ],
  "indications": [
    {
      "text": "ภาวะอักเสบและภูมิแพ้; รูปแบบ depot (Depo-Medrol) ใช้ในแมวเมื่อให้ยากินยาก; Solu-Medrol IV สำหรับภาวะเฉียบพลัน",
      "cites": [
        "merck-glucocorticoid"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "รูปแบบ depot ถอนกลับไม่ได้หากเกิดผลข้างเคียง; ข้อห้ามเหมือน glucocorticoid อื่น (เบาหวาน, ติดเชื้อ, NSAID ร่วม, แผล GI)",
      "cites": [
        "merck-glucocorticoid"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "PU/PD, polyphagia, ภูมิคุ้มกันลด, iatrogenic Cushing; depot form ออกฤทธิ์ยาวควบคุมยาก",
      "cites": [
        "merck-glucocorticoid"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Anti-inflammatory",
      "route": "PO",
      "dose": "0.5–1 mg/kg/วัน (anti-inflammatory; ใกล้เคียง prednisolone)",
      "notes": "Depo-Medrol depot: ยืนยันขนาด/ช่วงห่างกับ faculty",
      "cites": [
        "merck-glucocorticoid"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-glucocorticoid",
      "type": "textbook",
      "title": "Glucocorticoids / Anti-inflammatory Agents — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/anti-inflammatory-agents/corticosteroids",
      "note": "Merck corticosteroid pharmacology — anti-inflammatory vs immunosuppressive dosing + relative potency. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "dailymed-methylprednisolone",
      "type": "regulatory-database",
      "title": "Methylprednisolone — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=methylprednisolone",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "8e564b17eab789f9c6eac0e7e1bea7b8ba22b76353cc61306848bf530237e6e7"
    },
    {
      "id": "atc-H02AB04",
      "type": "guideline",
      "title": "ATC H02AB04 — Methylprednisolone",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=H02AB04&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "5b6c2aeb7ec659ba43b335378d861104928ed48cd1d72dcc0d905b7bb0a3099b"
    },
    {
      "id": "pubchem-methylprednisolone",
      "type": "monograph",
      "title": "Methylprednisolone — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Methylprednisolone",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "3cf15f5c7b8cf2ef1350268d1617d82cb6a879da04b07090d518b8865565b0bf"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=methylprednisolone",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=H02AB04&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Methylprednisolone",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "8e564b17eab789f9c6eac0e7e1bea7b8ba22b76353cc61306848bf530237e6e7",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "5b6c2aeb7ec659ba43b335378d861104928ed48cd1d72dcc0d905b7bb0a3099b",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "3cf15f5c7b8cf2ef1350268d1617d82cb6a879da04b07090d518b8865565b0bf",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "H02AB04",
      "name": "Methylprednisolone",
      "level": 5
    },
    "rxnorm": {
      "cui": "6902",
      "name": "Methylprednisolone"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 3 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM)). ATC H02AB04 + RxNorm 6902. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — methylprednisolone intermediate-acting profile + depot caution verified against Merck corticosteroids. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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