Verify Methocarbamol

Drug JSON

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{
  "slug": "methocarbamol",
  "nameEn": "Methocarbamol",
  "nameTh": "เมโทคาร์บามอล",
  "class": "Centrally-acting muscle relaxant",
  "mechanism": "ยาคลายกล้ามเนื้อออกฤทธิ์ที่ระบบประสาทกลาง (กดการนำสัญญาณ polysynaptic reflex ที่ไขสันหลัง) ลดการเกร็งของกล้ามเนื้อ; ไม่ได้คลายกล้ามเนื้อโดยตรงที่ neuromuscular junction",
  "brandNamesTh": [
    "Robaxin"
  ],
  "indications": [
    {
      "text": "คลายกล้ามเนื้อในภาวะเกร็งจากพิษ tremorgenic (เห็ด/รา, metaldehyde, strychnine, permethrin ในแมว) และอาการปวดกล้ามเนื้อ/กระดูก",
      "cites": [
        "merck-methocarbamol",
        "aspca-tremorgenic"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวังในไตบกพร่อง (ตัวทำละลาย polyethylene glycol ในรูปแบบฉีด); ฉีด IV เร็วทำให้ล้มลงและกดการหายใจ",
      "cites": [
        "merck-methocarbamol"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ง่วงซึม, อ่อนแรง, น้ำลายไหล, อาเจียน; ฉีด IV เร็วเกินทำให้กดการหายใจ",
      "cites": [
        "merck-methocarbamol"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Muscle spasm",
      "route": "PO",
      "dose": "20–30 mg/kg PO ทุก 8–12 ชั่วโมง",
      "cites": [
        "merck-methocarbamol"
      ]
    },
    {
      "species": "canine",
      "indication": "Tremorgenic toxicosis (severe)",
      "route": "IV",
      "dose": "55–220 mg/kg ช้า ๆ IV (ไม่เกิน 2 mL/นาที) ให้ซ้ำตามอาการ",
      "notes": "แมว/สุนัข: ขนาดสูงสำหรับพิษ tremorgenic; ให้ช้า ๆ เฝ้าระวังการหายใจ",
      "cites": [
        "merck-methocarbamol",
        "aspca-tremorgenic"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-methocarbamol",
      "type": "textbook",
      "title": "Muscle relaxants — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-musculoskeletal-system",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "aspca-tremorgenic",
      "type": "guideline",
      "title": "Tremorgenic mycotoxin intoxication — ASPCA Animal Poison Control",
      "year": 2024,
      "url": "https://www.aspcapro.org/sites/default/files/zo-toxbrief_0400.pdf",
      "note": "ASPCA toxicology brief — methocarbamol 55–220 mg/kg for tremorgenic toxicosis.",
      "cid": null
    },
    {
      "id": "wikipedia-Methocarbamol",
      "type": "monograph",
      "title": "Methocarbamol — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Methocarbamol",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "M03BA03",
      "name": "Methocarbamol",
      "level": 5
    },
    "rxnorm": {
      "cui": "6845",
      "name": "Methocarbamol"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / peer-reviewed studies), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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