Verify Methimazole

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "methimazole",
  "nameEn": "Methimazole",
  "nameTh": "เมไทมาโซล",
  "class": "Antithyroid — thyroid peroxidase inhibitor (feline hyperthyroidism)",
  "mechanism": "ยับยั้งเอนไซม์ thyroid peroxidase ขัดขวางการสร้างฮอร์โมนไทรอยด์ (T4/T3); ควบคุมแต่ไม่รักษาให้หาย จึงต้องให้ต่อเนื่อง; เป็นยาหลักของ feline hyperthyroidism",
  "brandNamesTh": [
    "Tapazole",
    "Felimazole"
  ],
  "indications": [
    {
      "text": "ภาวะไทรอยด์เป็นพิษในแมว (feline hyperthyroidism) — ควบคุมระดับฮอร์โมน; ใช้ก่อนผ่าตัด/รังสีบำบัด หรือเป็นการรักษาระยะยาว; มีรูปแบบ transdermal สำหรับแมวที่ป้อนยาก",
      "cites": [
        "merck-thyroid",
        "todaysvetpractice"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ระวังในแมวที่มีโรคไตซ่อนเร้น (การลดไทรอยด์อาจเผยภาวะไตวาย); ตรวจ CBC เพราะอาจกด bone marrow",
      "cites": [
        "merck-thyroid"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "เบื่ออาหาร อาเจียน ซึม (ช่วงแรก), อาการคันที่หน้า (facial excoriation), ตับอักเสบ, เม็ดเลือดต่ำ (blood dyscrasia); เผยภาวะไตวายที่ซ่อนอยู่",
      "cites": [
        "merck-thyroid"
      ]
    }
  ],
  "dosages": [
    {
      "species": "feline",
      "indication": "Hyperthyroidism",
      "route": "PO",
      "dose": "2.5 mg/ตัว ทุก 12 ชั่วโมง (เริ่มต้น 2 สัปดาห์) แล้วปรับตามระดับ T4; ส่วนใหญ่ต้องการ 5–7.5 mg/วัน",
      "cites": [
        "merck-thyroid",
        "todaysvetpractice"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-thyroid",
      "type": "textbook",
      "title": "Thyroid disease (hypo/hyperthyroidism) — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/endocrine-system/the-thyroid-gland/hyperthyroidism-in-animals",
      "note": "Merck endocrine reference — methimazole + levothyroxine dosing. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "todaysvetpractice",
      "type": "guideline",
      "title": "Today's Veterinary Practice — clinical pharmacology reviews",
      "year": 2024,
      "url": "https://todaysveterinarypractice.com/",
      "note": "Peer-reviewed veterinary clinical practice journal — methimazole, cyclosporine, epilepsy dosing reviews.",
      "cid": null
    },
    {
      "id": "dailymed-methimazole",
      "type": "regulatory-database",
      "title": "Methimazole — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=methimazole",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "7806ca0e56fae0933b6502565c9f094e6b09ffa955aa272862c690aa81680f8f"
    },
    {
      "id": "atc-H03BB02",
      "type": "guideline",
      "title": "ATC H03BB02 — Thiamazole (Methimazole)",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=H03BB02&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "b3492b960812fa2bf4aeabf5608c0b230461eed305bca31ac8da4fc304b691cb"
    },
    {
      "id": "pubchem-methimazole",
      "type": "monograph",
      "title": "Methimazole — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Methimazole",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "7603b5d778c96b682ba80bddf41ae78b729508dd26dba0b729e6bddb72ca25bf"
    },
    {
      "id": "who-eml-22",
      "type": "guideline",
      "title": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "year": 2021,
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "note": "Cross-checked source: drug appears on WHO EML — WHO recognizes its place in basic healthcare.",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=methimazole",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=H03BB02&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Methimazole",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    },
    {
      "id": "who-eml",
      "name": "WHO Model List of Essential Medicines (22nd List, 2021)",
      "url": "https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02",
      "asOfDate": "2026-05-27",
      "license": "CC BY-NC-SA 3.0 IGO"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "7806ca0e56fae0933b6502565c9f094e6b09ffa955aa272862c690aa81680f8f",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "b3492b960812fa2bf4aeabf5608c0b230461eed305bca31ac8da4fc304b691cb",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "7603b5d778c96b682ba80bddf41ae78b729508dd26dba0b729e6bddb72ca25bf",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "who-eml",
      "cid": "71030c795c4e0c0cff56566bfc9ae4ed448eab9188ae68ce773a50d9f7fc53eb",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "H03BB02",
      "name": "Thiamazole (Methimazole)",
      "level": 5
    },
    "rxnorm": {
      "cui": "6835",
      "name": "Methimazole"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 4 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM), WHO Model List of Essential Medicines (22nd List, 2021)). ATC H03BB02 + RxNorm 6835. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — methimazole 2.5 mg/cat q12h start + T4/renal monitoring verified against Merck thyroid + Today's Veterinary Practice. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ total T4, CBC, และค่าไต (BUN/creatinine) ที่ 2–3 สัปดาห์หลังเริ่มและทุกครั้งที่ปรับขนาด",
      "cites": [
        "merck-thyroid"
      ]
    }
  ]
}

Public keys used

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