Verify Meropenem

Drug JSON

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{
  "slug": "meropenem",
  "nameEn": "Meropenem",
  "nameTh": "เมโรพีเนม",
  "class": "Carbapenem (reserve broad-spectrum)",
  "mechanism": "β-lactam วงกว้างมากที่ยับยั้งการสร้างผนังเซลล์ ทนต่อ β-lactamase หลายชนิด ครอบคลุมแกรมบวก/ลบ/anaerobe — ยาสำรองสำหรับเชื้อดื้อยาหลายขนาน",
  "brandNamesTh": [
    "Meronem",
    "Merrem"
  ],
  "indications": [
    {
      "text": "การติดเชื้อดื้อยาหลายขนาน (MDR gram-negative เช่น ESBL E. coli) ที่ไม่ตอบสนองต่อยาอื่น — สงวนใช้ตาม stewardship",
      "cites": [
        "dailymed-meropenem",
        "plumbs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "แพ้ carbapenem/β-lactam; ปรับขนาดในโรคไต; ⚠️ จัดเป็นยาสำรองชั้นสูง ห้ามใช้เป็น first-line",
      "cites": [
        "dailymed-meropenem",
        "plumbs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "เจ็บ/บวมบริเวณฉีด (SC), ท้องเสีย, อาการแพ้; ชักเมื่อขนาดสูง/ไตบกพร่อง (พบน้อยกว่า imipenem)",
      "cites": [
        "plumbs",
        "wikipedia-Meropenem"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "MDR gram-negative infection",
      "route": "SC",
      "dose": "8.5–12 mg/kg SC/IV ทุก 8–12 ชั่วโมง (SC ดูดซึมดีในสุนัข เคส UTI ดื้อยา q12h)",
      "cites": [
        "plumbs",
        "dailymed-meropenem"
      ]
    },
    {
      "species": "feline",
      "indication": "MDR gram-negative infection",
      "route": "SC",
      "dose": "8.5 mg/kg SC/IV ทุก 8–12 ชั่วโมง",
      "cites": [
        "plumbs"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-J01DH02",
      "type": "regulatory-database",
      "title": "WHO ATC/DDD Index — Meropenem (J01DH02)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=J01DH02&showdescription=no",
      "note": "WHO Anatomical Therapeutic Chemical classification. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "dailymed-meropenem",
      "type": "package-insert",
      "title": "Meropenem — DailyMed (US FDA label)",
      "year": 2026,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=meropenem",
      "note": "US FDA structured product label. Authoritative for indications, contraindications, labeled use.",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Species doses cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "wikipedia-Meropenem",
      "type": "monograph",
      "title": "Meropenem — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Meropenem",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "J01DH02",
      "name": "Meropenem",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (WHO ATC / FDA label / Plumb’s / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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