Verify Pethidine (meperidine)

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "meperidine",
  "nameEn": "Pethidine (meperidine)",
  "nameTh": "เพทิดีน (เมเพอริดีน)",
  "class": "Opioid — short-acting μ-agonist (phenylpiperidine)",
  "mechanism": "กระตุ้น μ-opioid receptor ระงับปวด ออกฤทธิ์สั้น (~1–2 ชม.) มีฤทธิ์ spasmolytic เล็กน้อย ใช้ระงับปวดระยะสั้นและ premedication",
  "brandNamesTh": [
    "Demerol",
    "Pethidine"
  ],
  "indications": [
    {
      "text": "ระงับปวดระยะสั้นและ premedication ในสุนัข/แมว — ออกฤทธิ์เร็วแต่สั้น",
      "cites": [
        "dailymed-meperidine",
        "plumbs"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ห้ามฉีด IV (กระตุ้นการหลั่ง histamine → ความดันตก); ⚠️ ห้ามใช้ร่วม MAOI/selegiline (serotonin syndrome); ระวังในตับบกพร่อง (สะสม normeperidine ก่อชัก)",
      "cites": [
        "dailymed-meperidine",
        "plumbs"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ความดันตก/ปล่อย histamine ถ้าให้ IV, กดการหายใจ, ออกฤทธิ์สั้นต้องให้บ่อย",
      "cites": [
        "plumbs",
        "wikipedia-Pethidine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Short-term pain / premedication",
      "route": "IM",
      "dose": "3–5 mg/kg IM/SC ทุก 1–2 ชั่วโมง — ห้าม IV",
      "cites": [
        "plumbs",
        "dailymed-meperidine"
      ]
    },
    {
      "species": "feline",
      "indication": "Short-term pain / premedication",
      "route": "IM",
      "dose": "3–5 mg/kg IM/SC ทุก 1–2 ชั่วโมง — ห้าม IV",
      "cites": [
        "plumbs"
      ]
    }
  ],
  "citations": [
    {
      "id": "atc-N02AB02",
      "type": "regulatory-database",
      "title": "WHO ATC/DDD Index — Pethidine (meperidine) (N02AB02)",
      "year": 2026,
      "url": "https://www.whocc.no/atc_ddd_index/?code=N02AB02&showdescription=no",
      "note": "WHO Anatomical Therapeutic Chemical classification. Authoritative for class + INN.",
      "cid": null
    },
    {
      "id": "dailymed-meperidine",
      "type": "package-insert",
      "title": "Meperidine (pethidine) — DailyMed (US FDA label)",
      "year": 2026,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=meperidine",
      "note": "US FDA structured product label. Authoritative for indications, contraindications, labeled use.",
      "cid": null
    },
    {
      "id": "plumbs",
      "type": "textbook",
      "title": "Plumb's Veterinary Drug Handbook, 10th Edition",
      "authors": "Plumb DC",
      "year": 2023,
      "edition": "10th",
      "url": "https://www.plumbs.com/",
      "note": "Standard veterinary drug reference. Species doses cross-checked against this handbook.",
      "cid": null
    },
    {
      "id": "wikipedia-Pethidine",
      "type": "monograph",
      "title": "Pethidine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Pethidine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-06-07",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "N02AB02",
      "name": "Pethidine (meperidine)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-06-07",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-06-07",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-06-07",
      "summary": "New entry — clinical content compiled from cited authoritative sources (WHO ATC / FDA label / Plumb’s / VSSO), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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