Verify Melphalan

Drug JSON

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{
  "slug": "melphalan",
  "nameEn": "Melphalan",
  "nameTh": "เมลฟาแลน",
  "class": "Antineoplastic — alkylating agent (nitrogen mustard)",
  "mechanism": "alkylating agent กลุ่ม nitrogen mustard สร้าง DNA cross-link ยับยั้งการจำลอง DNA; เป็นหลักของการรักษา multiple myeloma คู่ prednisone",
  "brandNamesTh": [
    "Alkeran"
  ],
  "indications": [
    {
      "text": "multiple myeloma (คู่ prednisone), lymphoma บางชนิด และ macroglobulinemia ในสุนัขและแมว",
      "cites": [
        "vsso-melphalan",
        "dvm360-myeloma"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ยาเคมีบำบัด PPE; ⚠️ กดไขกระดูก (thrombocytopenia แบบสะสม/ล่าช้า — dose-limiting); ⚠️ ห้ามแบ่งเม็ดยา + ระวังขนาดในสุนัขตัวเล็ก (เสี่ยง overdose จากขนาดเม็ด)",
      "cites": [
        "vsso-melphalan",
        "dvm360-myeloma"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดไขกระดูก (thrombocytopenia สะสม), GI upset; พิษล่าช้าจึงต้องตรวจ CBC สม่ำเสมอ",
      "cites": [
        "dvm360-myeloma"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Multiple myeloma (with prednisone) — specialist",
      "route": "PO",
      "dose": "0.1 mg/kg PO วันละครั้ง นาน 10 วัน แล้วลดเป็น 0.05 mg/kg วันละครั้ง จน relapse หรือ myelosuppression — ⚠️ oncology only",
      "notes": "pulse: 7 mg/m² PO วันละครั้ง 5 วัน ทุก 21 วัน",
      "cites": [
        "vsso-melphalan",
        "dvm360-myeloma"
      ]
    },
    {
      "species": "feline",
      "indication": "Multiple myeloma — specialist",
      "route": "PO",
      "dose": "0.1 mg/kg PO วันละครั้ง นาน 10–14 วัน แล้ววันเว้นวันจนตอบสนอง/myelosuppression — ⚠️ oncology only",
      "cites": [
        "dvm360-myeloma"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ CBC สม่ำเสมอ (thrombocytopenia สะสม-ล่าช้า); ปรับ/หยุดเมื่อเกล็ดเลือดต่ำ",
      "cites": [
        "vsso-melphalan"
      ]
    }
  ],
  "citations": [
    {
      "id": "vsso-melphalan",
      "type": "guideline",
      "title": "Melphalan chemotherapy protocol — Veterinary Society of Surgical Oncology",
      "url": "https://www.vsso.org/chemotherapy-protocols",
      "year": 2024,
      "note": "VSSO chemotherapy protocol reference.",
      "cid": null
    },
    {
      "id": "dvm360-myeloma",
      "type": "guideline",
      "title": "An overview of multiple myeloma in dogs and cats — dvm360",
      "url": "https://www.dvm360.com/view/overview-multiple-myeloma-dogs-and-cats",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-melphalan",
      "type": "monograph",
      "title": "Melphalan — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Melphalan",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "L01AA03",
      "name": "Melphalan",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / EMA-FDA labels / VSSO / ACVIM-AAHA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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