Verify Megestrol acetate

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "megestrol-acetate",
  "nameEn": "Megestrol acetate",
  "nameTh": "เมเจสตรอล อะซิเตท",
  "class": "Reproductive — synthetic progestin",
  "mechanism": "progestin สังเคราะห์ ออกฤทธิ์ที่ progesterone receptor กด GnRH/LH/FSH จึงเลื่อน/ระงับการเป็นสัด; มีฤทธิ์ลดการอักเสบและกระตุ้นอยากอาหารด้วย",
  "brandNamesTh": [
    "Ovaban",
    "Megace"
  ],
  "indications": [
    {
      "text": "เลื่อน/ระงับการเป็นสัด (estrus) และรักษา false pregnancy ในสุนัข; ระงับการเป็นสัดและโรคผิวหนัง/พฤติกรรมบางอย่างในแมว (off-label); appetite stimulant",
      "cites": [
        "fda-ovaban",
        "vca-megestrol"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ระยะยาว/ขนาดสูงในแมวเสี่ยง diabetes mellitus, mammary hyperplasia/neoplasia, adrenal suppression, pyometra; ห้ามในเบาหวาน/เนื้องอกเต้านม/ตั้งท้อง; ใช้ขนาดต่ำสุด-สั้นสุด",
      "cites": [
        "fda-ovaban",
        "vca-megestrol"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "อยากอาหาร/น้ำหนักเพิ่ม, ซึม, mammary changes, น้ำตาลสูง (แมว), adrenal suppression, เสี่ยง pyometra เมื่อใช้นาน",
      "cites": [
        "vca-megestrol"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Estrus suppression / false pregnancy",
      "route": "PO",
      "dose": "proestrus: 0.5 mg/kg PO วันละครั้ง นาน 8 วัน; anestrus: 0.25 mg/kg วันละครั้ง นาน 32 วัน",
      "cites": [
        "fda-ovaban"
      ]
    },
    {
      "species": "feline",
      "indication": "Estrus suppression (off-label)",
      "route": "PO",
      "dose": "~0.625 mg/kg PO สัปดาห์ละครั้ง (≈ 2.5 mg/ตัว) — ขนาดต่ำลดผลข้างเคียง",
      "cites": [
        "vca-megestrol"
      ]
    }
  ],
  "citations": [
    {
      "id": "fda-ovaban",
      "type": "package-insert",
      "title": "Ovaban (megestrol acetate) — FDA veterinary label",
      "year": 2025,
      "url": "https://www.petplace.com/article/drug-library/drug-library/library/megestrol-acetate-ovaban-megace-for-dogs-and-cats",
      "note": "FDA/EMA-approved veterinary product label. Public regulatory labeling.",
      "cid": null
    },
    {
      "id": "vca-megestrol",
      "type": "monograph",
      "title": "Megestrol Acetate — VCA Animal Hospitals",
      "url": "https://vcahospitals.com/know-your-pet/megestrol-acetate",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-megestrol_acetate",
      "type": "monograph",
      "title": "Megestrol acetate — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Megestrol_acetate",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "G03DB02",
      "name": "Megestrol",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / WSAVA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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