Verify Mechlorethamine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "mechlorethamine",
  "nameEn": "Mechlorethamine",
  "nameTh": "เมคลอเรทามีน",
  "class": "Antineoplastic — nitrogen mustard alkylating agent",
  "mechanism": "nitrogen mustard alkylating agent สร้าง DNA cross-link ยับยั้งการจำลอง DNA; เป็นตัว \"M\" ในโปรโตคอล MOPP สำหรับ lymphoma ที่กลับเป็นซ้ำ",
  "brandNamesTh": [
    "Mustargen"
  ],
  "indications": [
    {
      "text": "lymphoma ที่กลับเป็นซ้ำหลัง CHOP ในสุนัข — องค์ประกอบหลักของ MOPP rescue protocol",
      "cites": [
        "vsso-mechlorethamine",
        "paper-mopp-b"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ยาเคมีบำบัด PPE; ⚠️ vesicant รุนแรงมาก (extravasation = เนื้อตายรุนแรง — ต้องสาย IV แน่นอน); กดไขกระดูก + GI toxicity (dose-limiting); ปรับในไตบกพร่อง",
      "cites": [
        "vsso-mechlorethamine",
        "paper-mopp-b"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดไขกระดูก, คลื่นไส้-อาเจียน, vesicant injury รุนแรงหากรั่ว",
      "cites": [
        "paper-mopp-b"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Relapsed lymphoma (MOPP) — specialist",
      "route": "IV",
      "dose": "3 mg/m² IV วันที่ 0 และ 7 ของรอบ 28 วัน — ⚠️ oncology only, vesicant, สาย IV แน่นอน",
      "notes": "ตรวจ CBC ก่อนทุกรอบ",
      "cites": [
        "vsso-mechlorethamine",
        "paper-mopp-b"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ CBC ก่อนทุกรอบ; ตรวจตำแหน่งให้ยา (vesicant)",
      "cites": [
        "vsso-mechlorethamine"
      ]
    }
  ],
  "citations": [
    {
      "id": "vsso-mechlorethamine",
      "type": "guideline",
      "title": "Mechlorethamine / MOPP chemotherapy protocol — Veterinary Society of Surgical Oncology",
      "url": "https://www.vsso.org/chemotherapy-protocols",
      "year": 2024,
      "note": "VSSO chemotherapy protocol reference.",
      "cid": null
    },
    {
      "id": "paper-mopp-b",
      "type": "paper",
      "title": "MOPP rescue protocol for relapsed canine lymphoma",
      "url": "https://pubmed.ncbi.nlm.nih.gov/17338160/",
      "year": 2023,
      "note": "Peer-reviewed canine lymphoma MOPP rescue study.",
      "cid": null
    },
    {
      "id": "wikipedia-chlormethine",
      "type": "monograph",
      "title": "Chlormethine (mechlorethamine) — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Chlormethine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "L01AA05",
      "name": "Chlormethine (mechlorethamine)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VSSO / FDA labels / dvm360 / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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