Verify Mavacoxib

Drug JSON

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{
  "slug": "mavacoxib",
  "nameEn": "Mavacoxib",
  "nameTh": "มาวาค็อกซิบ",
  "class": "NSAID — long-acting coxib (COX-2 selective, veterinary)",
  "mechanism": "NSAID กลุ่ม coxib ที่ยับยั้ง COX-2 อย่างจำเพาะและออกฤทธิ์ยาวมาก (ครึ่งชีวิตเป็นสัปดาห์) จึงให้แบบรายเดือน; สำหรับสุนัขโดยเฉพาะ (Trocoxil)",
  "brandNamesTh": [
    "Trocoxil"
  ],
  "indications": [
    {
      "text": "ควบคุมความปวดและการอักเสบจากโรคข้อเสื่อม (osteoarthritis) ในสุนัข ที่ต้องการรักษาต่อเนื่องเกิน 1 เดือน; ข้อดีคือให้รายเดือนเพิ่ม compliance",
      "cites": [
        "ema-trocoxil"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ครึ่งชีวิตยาวมาก — ถอนยากลับไม่ได้หากเกิดผลข้างเคียง; ห้ามในสุนัข < 12 เดือน/น้ำหนักน้อย, โรคไต/ตับ/หัวใจ, แผล GI, ขาดน้ำ; ห้ามใช้ร่วม NSAID อื่น/corticosteroid",
      "cites": [
        "ema-trocoxil"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "GI (อาเจียน ท้องเสีย), ผลต่อไต/ตับ; เนื่องจากออกฤทธิ์ยาว ผลข้างเคียงอาจคงอยู่นานหลังหยุด",
      "cites": [
        "ema-trocoxil"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Osteoarthritis (chronic)",
      "route": "PO",
      "dose": "2 mg/kg PO พร้อม/ก่อนอาหารมื้อหลัก, ให้ซ้ำที่ 14 วัน จากนั้นทุก 1 เดือน",
      "duration": "รอบการรักษาไม่เกิน 7 โดสติดต่อกัน (~6.5 เดือน)",
      "cites": [
        "ema-trocoxil"
      ]
    }
  ],
  "citations": [
    {
      "id": "ema-trocoxil",
      "type": "package-insert",
      "title": "Trocoxil (mavacoxib) — EMA Summary of Product Characteristics",
      "year": 2021,
      "url": "https://ec.europa.eu/health/documents/community-register/2021/20210426151538/anx_151538_en.pdf",
      "note": "EMA SPC — canine 2 mg/kg, repeat at 14 days then monthly, max 7 consecutive doses. Authoritative regulatory label.",
      "cid": null
    },
    {
      "id": "dailymed-mavacoxib",
      "type": "regulatory-database",
      "title": "Mavacoxib — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=mavacoxib",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "bcfccb438ae989747cda16e4b734765a6cd0033ea1bf0d375da331a2d8abb057"
    },
    {
      "id": "atc-QM01AH92",
      "type": "guideline",
      "title": "ATC QM01AH92 — Mavacoxib (veterinary, long-acting)",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=QM01AH92&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "a7e069f2bd56018ce5e649742f5ac3fb03ec87e225a74fec53494e77e5a2bf97"
    },
    {
      "id": "pubchem-mavacoxib",
      "type": "monograph",
      "title": "Mavacoxib — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Mavacoxib",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "e4b28f49227ab517493bd8b4f9fbe8adb3fd484a126146b567938ac631d43ddc"
    },
    {
      "id": "wsava-pain-2022",
      "type": "guideline",
      "title": "WSAVA Global Pain Council — Guidelines for Recognition, Assessment and Treatment of Pain",
      "year": 2022,
      "url": "https://wsava.org/global-guidelines/global-pain-council-guidelines/",
      "note": "Cross-checked source: WSAVA global vet community standard for pain management.",
      "cid": "4f3dfbc8262369e4ed25263fc5fd4051710cda271692dda3c34ef6bcf96b22aa"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=mavacoxib",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=QM01AH92&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Mavacoxib",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    },
    {
      "id": "wsava-pain",
      "name": "WSAVA Global Pain Council guidelines",
      "url": "https://wsava.org/global-guidelines/global-pain-council-guidelines/",
      "asOfDate": "2026-05-27",
      "license": "Free for educational use with attribution"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "bcfccb438ae989747cda16e4b734765a6cd0033ea1bf0d375da331a2d8abb057",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "a7e069f2bd56018ce5e649742f5ac3fb03ec87e225a74fec53494e77e5a2bf97",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "e4b28f49227ab517493bd8b4f9fbe8adb3fd484a126146b567938ac631d43ddc",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "wsava-pain",
      "cid": "4f3dfbc8262369e4ed25263fc5fd4051710cda271692dda3c34ef6bcf96b22aa",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "QM01AH92",
      "name": "Mavacoxib (veterinary, long-acting)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 4 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM), WSAVA Global Pain Council guidelines). ATC QM01AH92 (vet-only, no human RxNorm CUI). Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — mavacoxib 2 mg/kg, repeat at 14 days then monthly, max 7 consecutive doses, with long-half-life irreversibility warning verified against EMA Trocoxil SPC. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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