Verify Loperamide

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "loperamide",
  "nameEn": "Loperamide",
  "nameTh": "โลเพอราไมด์",
  "class": "Intestinal — opioid antidiarrheal (antipropulsive)",
  "mechanism": "opioid agonist ที่ออกฤทธิ์เฉพาะที่ลำไส้ (ไม่ผ่าน CNS ในขนาดปกติ) — ลดการบีบตัวของลำไส้ (antipropulsive) เพิ่มการดูดน้ำกลับ จึงลดท้องเสีย",
  "brandNamesTh": [
    "Imodium"
  ],
  "indications": [
    {
      "text": "ท้องเสียเฉียบพลันแบบ non-infectious / secretory ในสุนัข (ระยะสั้น) — ลดความถี่อุจจาระ",
      "cites": [
        "vca-loperamide",
        "merck-antidiarrheal"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ห้ามในสุนัขที่มี MDR1/ABCB1 mutation (Collie, Australian Shepherd ฯลฯ) — P-glycoprotein บกพร่อง ทำให้ยาเข้า CNS เกิดพิษประสาทรุนแรง; ห้ามในท้องเสียติดเชื้อ/มีพิษ (กักเชื้อ/สารพิษ); ระวังในแมว (ไวต่อ opioid excitation)",
      "cites": [
        "vca-loperamide",
        "merck-antidiarrheal"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ท้องผูก ซึม; ในสุนัข MDR1 → ataxia ซึมลึก น้ำลายไหล (พิษ CNS); ในแมวอาจตื่นเต้น",
      "cites": [
        "vca-loperamide"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Acute non-infectious diarrhea",
      "route": "PO",
      "dose": "0.08–0.2 mg/kg PO ทุก 8–12 ชั่วโมง ตามต้องการ (ระยะสั้น) — ⚠️ เลี่ยงในพันธุ์เสี่ยง MDR1",
      "cites": [
        "vca-loperamide",
        "merck-antidiarrheal"
      ]
    }
  ],
  "citations": [
    {
      "id": "vca-loperamide",
      "type": "monograph",
      "title": "Loperamide — VCA Animal Hospitals",
      "url": "https://vcahospitals.com/know-your-pet/loperamide",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "merck-antidiarrheal",
      "type": "textbook",
      "title": "Antidiarrheal Drugs (Drugs that Affect Digestive Functions) — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-digestive-system/drugs-that-affect-digestive-functions-in-monogastric-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-loperamide",
      "type": "monograph",
      "title": "Loperamide — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Loperamide",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "A07DA03",
      "name": "Loperamide",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VCA / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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