Verify Liothyronine (T3)

Drug JSON

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{
  "slug": "liothyronine",
  "nameEn": "Liothyronine (T3)",
  "nameTh": "ไลโอไทโรนีน (T3)",
  "class": "Endocrine — synthetic thyroid hormone (T3)",
  "mechanism": "รูปสังเคราะห์ของ triiodothyronine (T3) — ฮอร์โมนไทรอยด์ที่ออกฤทธิ์โดยตรง (levothyroxine/T4 ต้องแปลงเป็น T3 ก่อน); ใช้น้อยกว่า levothyroxine แต่ใช้ใน T3 suppression test",
  "brandNamesTh": [
    "Cytomel",
    "Liothyronine"
  ],
  "indications": [
    {
      "text": "hypothyroidism ในสุนัขที่ไม่ตอบสนอง/ดูดซึม levothyroxine ไม่ดี (ใช้น้อยกว่า T4), และเป็นยาใน T3 suppression test สำหรับวินิจฉัย hyperthyroidism แมว",
      "cites": [
        "vetdrugs-liothyronine",
        "tvp-hypothyroid"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "levothyroxine (T4) เป็นทางเลือกแรกของ hypothyroidism (T3 ออกฤทธิ์สั้นต้องให้บ่อย q8h); ระวัง thyrotoxicosis (หัวใจเต้นเร็ว PU/PD น้ำหนักลด); ระวังในโรคหัวใจ/ต่อมหมวกไตวาย",
      "cites": [
        "vetdrugs-liothyronine",
        "tvp-hypothyroid"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "thyrotoxicosis เมื่อเกินขนาด (หัวใจเต้นเร็ว กระวนกระวาย หอบ PU/PD น้ำหนักลด)",
      "cites": [
        "vetdrugs-liothyronine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Hypothyroidism (when T4 inadequate)",
      "route": "PO",
      "dose": "2–6 mcg/kg PO ทุก 8–12 ชั่วโมง",
      "cites": [
        "vetdrugs-liothyronine",
        "tvp-hypothyroid"
      ]
    },
    {
      "species": "feline",
      "indication": "T3 suppression test (diagnostic)",
      "route": "PO",
      "dose": "25 mcg/ตัว PO ทุก 8 ชั่วโมง รวม 7 โดส (2 วัน) แล้ววัด T4/T3 — ใช้วินิจฉัย hyperthyroid",
      "cites": [
        "vetdrugs-liothyronine"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ T4/T3 + อาการทางคลินิก; เฝ้า thyrotoxicosis",
      "cites": [
        "tvp-hypothyroid"
      ]
    }
  ],
  "citations": [
    {
      "id": "vetdrugs-liothyronine",
      "type": "guideline",
      "title": "Liothyronine (T3) veterinary dosing — Vet Drugs List",
      "url": "https://www.vet-ebooks.com/vetdrugslist/liothyronine-t3-l-tri-iodothyronine/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "tvp-hypothyroid",
      "type": "guideline",
      "title": "Canine Hypothyroidism: Diagnosis and Treatment — Today's Veterinary Practice",
      "url": "https://todaysveterinarypractice.com/endocrinology/canine-hypothyroidism-diagnosis-and-treatment/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-liothyronine",
      "type": "monograph",
      "title": "Liothyronine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Liothyronine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "H03AA02",
      "name": "Liothyronine sodium (T3)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VCA / EveryCat / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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