Verify Lidocaine

Drug JSON

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{
  "slug": "lidocaine",
  "nameEn": "Lidocaine",
  "nameTh": "ลิโดเคน",
  "class": "Antiarrhythmic class Ib + local anesthetic",
  "mechanism": "ปิดกั้น sodium channel ของเซลล์ ออกฤทธิ์เป็น antiarrhythmic class Ib (คุม ventricular arrhythmia) และเป็น local anesthetic; ออกฤทธิ์เร็วและสั้น",
  "brandNamesTh": [
    "Lidocaine",
    "Xylocaine"
  ],
  "indications": [
    {
      "text": "ยาเลือกแรกสำหรับ ventricular tachyarrhythmia เฉียบพลันในสุนัข (IV); ใช้เป็น local/regional anesthetic และเป็นส่วนหนึ่งของ CRI ระงับปวด (MLK: morphine-lidocaine-ketamine)",
      "cites": [
        "merck-antiarrhythmics-b",
        "vetgirl-lidocaine"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ แมวไวต่อพิษมาก (neurotoxicity, cardiovascular collapse) — ใช้ขนาดต่ำมากและระวังสูง; ห้ามใช้สูตรที่ผสม epinephrine ทาง IV",
      "cites": [
        "merck-antiarrhythmics-b",
        "vetgirl-lidocaine"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "พิษต่อระบบประสาท (กระตุก ชัก), คลื่นไส้, ความดันต่ำ; แมวเกิดพิษได้ที่ขนาดต่ำกว่าสุนัขมาก",
      "cites": [
        "vetgirl-lidocaine"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Ventricular tachyarrhythmia",
      "route": "IV",
      "dose": "2 mg/kg IV bolus ช้า ๆ (ซ้ำได้ถึงรวม 8 mg/kg ใน ~30 นาที) จากนั้น CRI 25–100 mcg/kg/min",
      "cites": [
        "merck-antiarrhythmics-b",
        "vetgirl-lidocaine"
      ]
    },
    {
      "species": "feline",
      "indication": "Ventricular arrhythmia (rare, extreme caution)",
      "route": "IV",
      "dose": "0.1–0.4 mg/kg IV bolus ช้า ๆ (รวมไม่เกิน 0.25–1 mg/kg), CRI 10–20 mcg/kg/min — ⚠️ แมวไวต่อพิษมาก",
      "cites": [
        "vetgirl-lidocaine"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-antiarrhythmics-b",
      "type": "textbook",
      "title": "Antiarrhythmics for Use in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-cardiovascular-system/antiarrhythmics-for-use-in-animals",
      "note": "Merck — lidocaine ventricular antiarrhythmic dosing. Copyrighted, cited.",
      "cid": null
    },
    {
      "id": "vetgirl-lidocaine",
      "type": "guideline",
      "title": "Lidocaine for treatment of ventricular tachycardia — VETgirl",
      "year": 2024,
      "url": "https://vetgirlontherun.com/lidocaine-for-treatment-of-ventricular-tachycardia-vetgirl-veterinary-continuing-education-blog/",
      "note": "Veterinary CE — canine bolus/CRI + feline sensitivity. Secondary reference.",
      "cid": null
    },
    {
      "id": "wikipedia-Lidocaine",
      "type": "monograph",
      "title": "Lidocaine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Lidocaine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "C01BB01",
      "name": "Lidocaine (antiarrhythmic)",
      "level": 5
    },
    "rxnorm": {
      "cui": "6387",
      "name": "Lidocaine"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / peer-reviewed studies), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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