Verify Levetiracetam

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "levetiracetam",
  "nameEn": "Levetiracetam",
  "nameTh": "เลเวทิราซีแทม",
  "class": "Anticonvulsant — SV2A modulator (adjunct AED)",
  "mechanism": "ยากันชักออกฤทธิ์จับ synaptic vesicle protein 2A (SV2A) ปรับการปล่อย neurotransmitter; กลไกต่างจาก phenobarbital จึงใช้เสริม; ข้อดีคือไม่เป็นพิษต่อตับและ drug interaction น้อย",
  "brandNamesTh": [
    "Keppra"
  ],
  "indications": [
    {
      "text": "ยากันชักเสริม (add-on) ในสุนัขและแมวที่คุมชักไม่ได้ด้วย phenobarbital เดี่ยว; ใช้ในสัตว์ที่มีโรคตับ (ไม่ผ่านตับ); รูปแบบ IV ใช้ใน status epilepticus",
      "cites": [
        "merck-levetiracetam",
        "tvp-aed"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "ปรับลดขนาดในไตบกพร่อง (ขับทางไต); ห้ามหยุดกะทันหัน; ครึ่งชีวิตสั้นในสุนัขจึงต้องให้ทุก 8 ชั่วโมง",
      "cites": [
        "merck-levetiracetam"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ง่วงซึม, เดินเซ (ชั่วคราว), การเปลี่ยนแปลงพฤติกรรมเล็กน้อย; โดยรวมปลอดภัยสูง",
      "cites": [
        "merck-levetiracetam"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Adjunct anticonvulsant",
      "route": "PO",
      "dose": "20 mg/kg PO ทุก 8 ชั่วโมง (ปรับขึ้นได้ถึง 60 mg/kg q8h)",
      "cites": [
        "merck-levetiracetam",
        "tvp-aed"
      ]
    },
    {
      "species": "feline",
      "indication": "Adjunct anticonvulsant",
      "route": "PO",
      "dose": "20 mg/kg PO ทุก 8 ชั่วโมง",
      "cites": [
        "tvp-aed"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-levetiracetam",
      "type": "textbook",
      "title": "Epilepsy in Small Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/nervous-system/epilepsy-in-small-animals/epilepsy-in-small-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "tvp-aed",
      "type": "guideline",
      "title": "Antiseizure Medications for Dogs and Cats — Today's Veterinary Practice",
      "url": "https://todaysveterinarypractice.com/pharmacology/antiseizure-medications-for-dogs-and-cats/",
      "year": 2024,
      "note": "Peer-reviewed veterinary clinical practice journal.",
      "cid": null
    },
    {
      "id": "wikipedia-Levetiracetam",
      "type": "monograph",
      "title": "Levetiracetam — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Levetiracetam",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "N03AX14",
      "name": "Levetiracetam",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / peer-reviewed studies), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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