Verify Latanoprost

Drug JSON

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{
  "slug": "latanoprost",
  "nameEn": "Latanoprost",
  "nameTh": "ลาทาโนพรอสต์",
  "class": "Ophthalmology — prostaglandin F2α analogue (glaucoma; ⚠️ not for cats)",
  "mechanism": "ยาหยอดตากลุ่ม prostaglandin analogue เพิ่มการระบาย aqueous humor ทาง uveoscleral pathway ลดความดันลูกตาได้แรงและเร็ว; เป็นยาเลือกแรกใน acute glaucoma ของสุนัข",
  "brandNamesTh": [
    "Xalatan"
  ],
  "indications": [
    {
      "text": "ลดความดันลูกตาใน glaucoma ของสุนัข โดยเฉพาะภาวะเฉียบพลัน (ออกฤทธิ์เร็ว ทำให้รูม่านตาหด/miosis); ⚠️ ประสิทธิภาพในแมวต่ำ (แมวขาด FP receptor)",
      "cites": [
        "merck-ophthalmic-b",
        "tvp-glaucoma-b"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ห้ามใช้ใน anterior lens luxation และ uveitis (การหด miosis เป็นอันตราย); ประสิทธิภาพในแมวจำกัด; ใช้เฉพาะที่",
      "cites": [
        "merck-ophthalmic-b",
        "tvp-glaucoma-b"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "รูม่านตาหด (miosis), เยื่อบุตาแดง, ระคายเคืองเฉพาะที่; เพิ่มสีม่านตา (iris pigmentation) เมื่อใช้นาน",
      "cites": [
        "merck-ophthalmic-b"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Glaucoma (esp. acute)",
      "route": "ocular",
      "dose": "หยอดตา 0.005% ข้างที่เป็น ทุก 12–24 ชั่วโมง (acute crisis อาจถี่กว่าตามคำแนะนำจักษุแพทย์)",
      "cites": [
        "merck-ophthalmic-b",
        "tvp-glaucoma-b"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-ophthalmic-b",
      "type": "textbook",
      "title": "Ophthalmic Pharmacology and Therapeutics — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/eye-diseases-and-disorders/ophthalmology/ophthalmic-pharmacology-and-therapeutics",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "tvp-glaucoma-b",
      "type": "guideline",
      "title": "Medical Management of Glaucoma — Today's Veterinary Practice",
      "year": 2024,
      "url": "https://todaysveterinarypractice.com/ophthalmology/medical-management-of-glaucoma/",
      "note": "Peer-reviewed clinical reference — prostaglandin analogue first-line canine glaucoma, feline limitation.",
      "cid": null
    },
    {
      "id": "wikipedia-latanoprost",
      "type": "monograph",
      "title": "Latanoprost — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Latanoprost",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "S01EE01",
      "name": "Latanoprost",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VCA / VSSO chemo protocols / FDA-EMA labels / Today's Vet Practice), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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