Verify Ketoprofen

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "ketoprofen",
  "nameEn": "Ketoprofen",
  "nameTh": "คีโตโพรเฟน",
  "class": "NSAID — propionic acid derivative (nonselective)",
  "mechanism": "ยากลุ่ม NSAID อนุพันธ์ propionic acid; ยับยั้ง COX แบบ nonselective (ทั้ง COX-1 และ COX-2) และยับยั้ง bradykinin กับ lipoxygenase บางส่วน; t½ สั้น ~2-3 ชั่วโมง",
  "brandNamesTh": [
    "Ketofen",
    "Romefen"
  ],
  "indications": [
    {
      "text": "สุนัขและแมว — ควบคุมความปวดและการอักเสบเฉียบพลัน (เช่น หลังผ่าตัด); ประสิทธิภาพคุมปวดเทียบเท่า opioid ในบางสถานการณ์ — ใช้ระยะสั้นเท่านั้น",
      "cites": [
        "merck-vet-nsaid"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "เป็น nonselective NSAID จึงเสี่ยงต่อ GI และไตสูงกว่ากลุ่ม COX-2 preferential; ห้ามใช้ในโรคไต/ตับ, ความผิดปกติการแข็งตัวของเลือด; มีฤทธิ์ antiplatelet จึงต้องระวังเป็นพิเศษช่วง perioperative",
      "cites": [
        "merck-vet-nsaid"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ระบบทางเดินอาหาร (GI upset), hepatopathy, โรคไต; ฤทธิ์ antiplatelet ทำให้เลือดออกง่ายขึ้น",
      "cites": [
        "merck-vet-nsaid"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Acute pain / inflammation (short-term)",
      "route": "PO",
      "dose": "1 mg/kg วันละครั้ง — สูงสุด 5 วัน",
      "duration": "ไม่เกิน 5 วัน",
      "notes": "อาจให้ IV/SC ในวันแรก; ห้ามใช้ต่อเนื่องเกิน 5 วันตาม Merck",
      "cites": [
        "merck-vet-nsaid"
      ]
    },
    {
      "species": "feline",
      "indication": "Acute pain / inflammation (short-term)",
      "route": "PO",
      "dose": "1 mg/kg วันละครั้ง — สูงสุด 5 วัน",
      "duration": "ไม่เกิน 5 วัน",
      "notes": "ใช้ระยะสั้น; ระวังผลต่อไตในแมว",
      "cites": [
        "merck-vet-nsaid"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-vet-nsaid",
      "type": "textbook",
      "title": "NSAIDs in Animals — MSD/Merck Veterinary Manual (Pharmacology)",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/anti-inflammatory-agents/nonsteroidal-anti-inflammatory-drugs-in-animals",
      "note": "Authoritative veterinary pharmacology reference — verified canine dose, COX selectivity, adverse-effect profile. Copyrighted — cited, not mirrored.",
      "cid": null
    },
    {
      "id": "wikipedia-ketoprofen",
      "type": "monograph",
      "title": "Ketoprofen — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Ketoprofen",
      "note": "Tertiary cross-check for class, mechanism, brand names. CC BY-SA 4.0. Not sole authority for any clinical claim.",
      "cid": null
    },
    {
      "id": "dailymed-ketoprofen",
      "type": "regulatory-database",
      "title": "Ketoprofen — NLM DailyMed (FDA Structured Product Labeling)",
      "year": 2025,
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=ketoprofen",
      "note": "Cross-checked source: FDA-approved labeling. Search by name returns relevant product labelings.",
      "cid": "bb48b8598f39c9e68e580d020ec90a21d7667e5148d856edb57b4b8238ccfe0b"
    },
    {
      "id": "atc-M01AE03",
      "type": "guideline",
      "title": "ATC M01AE03 — Ketoprofen",
      "year": 2025,
      "url": "https://www.whocc.no/atc_ddd_index/?code=M01AE03&showdescription=no",
      "note": "Cross-checked source: WHO Collaborating Centre ATC/DDD index. Authoritative drug classification.",
      "cid": "90aec6700b3bf1d8cd14bef698f7512b6a1ef33dfd4de87f62a41abd2b9fa9ad"
    },
    {
      "id": "pubchem-ketoprofen",
      "type": "monograph",
      "title": "Ketoprofen — PubChem search",
      "year": 2025,
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Ketoprofen",
      "note": "Cross-checked source: chemical structure, identifiers, pharmacology summary. Faculty review fills exact CID.",
      "cid": "dfdfb148f847627038097765866cbf8afbd146f8b39b1152e5d577738e1ff724"
    },
    {
      "id": "wsava-pain-2022",
      "type": "guideline",
      "title": "WSAVA Global Pain Council — Guidelines for Recognition, Assessment and Treatment of Pain",
      "year": 2022,
      "url": "https://wsava.org/global-guidelines/global-pain-council-guidelines/",
      "note": "Cross-checked source: WSAVA global vet community standard for pain management.",
      "cid": "4f3dfbc8262369e4ed25263fc5fd4051710cda271692dda3c34ef6bcf96b22aa"
    }
  ],
  "mirroredFrom": [
    {
      "id": "dailymed",
      "name": "NLM DailyMed",
      "url": "https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=ketoprofen",
      "asOfDate": "2026-05-27",
      "license": "U.S. Government work — public domain. Attribution recommended."
    },
    {
      "id": "atc",
      "name": "WHO ATC Classification",
      "url": "https://www.whocc.no/atc_ddd_index/?code=M01AE03&showdescription=no",
      "asOfDate": "2026-05-27",
      "license": "WHO publication, free for use with attribution"
    },
    {
      "id": "pubchem",
      "name": "PubChem (NIH/NLM)",
      "url": "https://pubchem.ncbi.nlm.nih.gov/#query=Ketoprofen",
      "asOfDate": "2026-05-27",
      "license": "NIH/NLM public domain"
    },
    {
      "id": "wsava-pain",
      "name": "WSAVA Global Pain Council guidelines",
      "url": "https://wsava.org/global-guidelines/global-pain-council-guidelines/",
      "asOfDate": "2026-05-27",
      "license": "Free for educational use with attribution"
    }
  ],
  "mirrorCIDs": [
    {
      "sourceId": "dailymed",
      "cid": "bb48b8598f39c9e68e580d020ec90a21d7667e5148d856edb57b4b8238ccfe0b",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "atc",
      "cid": "90aec6700b3bf1d8cd14bef698f7512b6a1ef33dfd4de87f62a41abd2b9fa9ad",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "pubchem",
      "cid": "dfdfb148f847627038097765866cbf8afbd146f8b39b1152e5d577738e1ff724",
      "capturedAt": "2026-05-27",
      "status": "stub"
    },
    {
      "sourceId": "wsava-pain",
      "cid": "4f3dfbc8262369e4ed25263fc5fd4051710cda271692dda3c34ef6bcf96b22aa",
      "capturedAt": "2026-05-27",
      "status": "stub"
    }
  ],
  "codes": {
    "atc": {
      "code": "M01AE03",
      "name": "Ketoprofen",
      "level": 5
    },
    "rxnorm": {
      "cui": "6142",
      "name": "Ketoprofen"
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-27",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-27",
  "version": 1,
  "changelog": [
    {
      "version": 0,
      "date": "2026-05-27",
      "summary": "Seed entry — cross-checked from 4 authoritative sources (NLM DailyMed, WHO ATC Classification, PubChem (NIH/NLM), WSAVA Global Pain Council guidelines). ATC M01AE03 + RxNorm 6142. Thai translation + faculty review pending."
    },
    {
      "version": 1,
      "date": "2026-05-27",
      "summary": "Clinical content compiled from cited sources — canine + feline dose 1 mg/kg/day max 5 days verified against Merck Veterinary Manual. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ],
  "interactions": [
    {
      "text": "เพิ่มความเสี่ยงเลือดออก/เป็นพิษเมื่อใช้ร่วมกับ NSAID อื่น, anticoagulant, corticosteroid หรือยาพิษต่อไต",
      "cites": [
        "merck-vet-nsaid"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "เฝ้าระวังอาการ GI และภาวะเลือดออก โดยเฉพาะช่วงผ่าตัด; ตรวจค่าไต/ตับหากจำเป็น",
      "cites": [
        "merck-vet-nsaid"
      ]
    }
  ]
}

Public keys used

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