Verify Protamine zinc insulin (PZI)

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "insulin-pzi",
  "nameEn": "Protamine zinc insulin (PZI)",
  "nameTh": "อินซูลิน PZI",
  "class": "Diabetes — long-acting insulin (feline first-line)",
  "mechanism": "recombinant human insulin จับ protamine + zinc ให้ดูดซึมช้า ออกฤทธิ์ยาว — เป็น insulin ทางเลือกแรกของเบาหวานแมว (ProZinc, รับรองสำหรับแมวและสุนัข)",
  "brandNamesTh": [
    "ProZinc"
  ],
  "indications": [
    {
      "text": "เบาหวาน (diabetes mellitus) ในแมว — insulin ทางเลือกแรกที่ FDA รับรอง (ProZinc); รับรองในสุนัขด้วย",
      "cites": [
        "fda-prozinc",
        "cb-insulins"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ใช้ U-40 syringe เท่านั้น (40 IU/mL — ใช้ syringe ผิดขนาด = dosing ผิด); ⚠️ hypoglycemia เป็นความเสี่ยงหลัก; กลิ้งขวดเบา ๆ (ห้ามเขย่า); ให้พร้อม/หลังอาหาร; ปรับขนาดหลัง glucose curve เท่านั้น",
      "cites": [
        "fda-prozinc"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "น้ำตาลต่ำ (อ่อนแรง ชัก โคม่า), Somogyi rebound เมื่อขนาดสูงเกิน; ปฏิกิริยาจุดฉีดพบน้อย",
      "cites": [
        "fda-prozinc"
      ]
    }
  ],
  "dosages": [
    {
      "species": "feline",
      "indication": "Diabetes mellitus (newly diagnosed)",
      "route": "SC",
      "dose": "เริ่ม 0.2–0.7 IU/kg (0.1–0.3 IU/lb) SC ทุก 12 ชั่วโมง พร้อม/หลังอาหาร; ปรับตาม glucose curve",
      "cites": [
        "fda-prozinc",
        "cb-insulins"
      ]
    },
    {
      "species": "canine",
      "indication": "Diabetes mellitus",
      "route": "SC",
      "dose": "~0.5 IU/kg SC ทุก 12 ชั่วโมง ปรับตามการตอบสนอง (ProZinc รับรองในสุนัขด้วย)",
      "cites": [
        "fda-prozinc"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "blood glucose curve / continuous glucose monitor + fructosamine; ประเมิน 5–7 วันก่อนปรับ",
      "cites": [
        "fda-prozinc"
      ]
    }
  ],
  "citations": [
    {
      "id": "fda-prozinc",
      "type": "package-insert",
      "title": "ProZinc (protamine zinc recombinant human insulin) — FDA veterinary label",
      "year": 2025,
      "url": "https://www.drugs.com/vet/prozinc-protamine-zinc-recombinant-human-insulin-for-cats-and-dogs.html",
      "note": "FDA/EMA-approved veterinary product label. Public regulatory labeling.",
      "cid": null
    },
    {
      "id": "cb-insulins",
      "type": "guideline",
      "title": "Top 5 Maintenance Insulins for Use in Veterinary Medicine — Clinician's Brief",
      "url": "https://www.cliniciansbrief.com/article/top-5-maintenance-insulins",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-protamine_zinc_insulin",
      "type": "monograph",
      "title": "Protamine zinc insulin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Protamine_zinc_insulin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "A10AC01",
      "name": "Insulin (human) — isophane/protamine zinc",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VCA / EveryCat / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

[]