Verify NPH insulin (isophane)

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "insulin-nph",
  "nameEn": "NPH insulin (isophane)",
  "nameTh": "อินซูลิน NPH",
  "class": "Diabetes — intermediate-acting insulin",
  "mechanism": "human insulin ตกผลึกกับ protamine + zinc (isophane) ออกฤทธิ์ระดับ intermediate — ใช้คุมเบาหวานสุนัขเป็นหลัก (ออกฤทธิ์สั้นกว่า PZI จึงเหมาะกับ metabolism สุนัข)",
  "brandNamesTh": [
    "Humulin N",
    "Novolin N"
  ],
  "indications": [
    {
      "text": "เบาหวาน (diabetes mellitus) ในสุนัข — insulin ทางเลือกที่ใช้บ่อย (ออกฤทธิ์ 4–10 ชม. เหมาะกับสุนัข); ใช้ในแมวได้แต่ออกฤทธิ์สั้นเกินในบางตัว",
      "cites": [
        "cb-insulins-b",
        "akovet-insulin"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ U-100 insulin (100 IU/mL) — ใช้ U-100 syringe; ⚠️ hypoglycemia; ออกฤทธิ์สั้นในบางสุนัข (อาจต้อง q12h สม่ำเสมอ); ปรับขนาดทีละ ~10–25% ทุก ~7 วันหลัง glucose curve",
      "cites": [
        "cb-insulins-b",
        "akovet-insulin"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "น้ำตาลต่ำ, Somogyi rebound; ระยะออกฤทธิ์สั้นอาจคุมไม่ทั้งวัน",
      "cites": [
        "akovet-insulin"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Diabetes mellitus (newly diagnosed)",
      "route": "SC",
      "dose": "เริ่ม 0.25–0.5 IU/kg SC ทุก 12 ชั่วโมง (ปัดเป็นจำนวนเต็ม); ส่วนใหญ่คุมได้ที่ 0.5–1 IU/kg q12h",
      "cites": [
        "cb-insulins-b",
        "akovet-insulin"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "blood glucose curve; ปรับ ~10–25% แล้วรอ ~7 วันก่อนทำ curve ซ้ำ",
      "cites": [
        "akovet-insulin"
      ]
    }
  ],
  "citations": [
    {
      "id": "cb-insulins-b",
      "type": "guideline",
      "title": "Top 5 Maintenance Insulins for Use in Veterinary Medicine — Clinician's Brief",
      "url": "https://www.cliniciansbrief.com/article/top-5-maintenance-insulins",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "akovet-insulin",
      "type": "guideline",
      "title": "Insulin Plan for diabetic dogs — AkoVet",
      "url": "https://akovet.org/resource-hub/for-animal-owners/owners-dogs-home/dog-diabetes-mellitus/dog-diabetes-insulin/",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-nph_insulin",
      "type": "monograph",
      "title": "NPH insulin — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/NPH_insulin",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-31",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "A10AC01",
      "name": "Insulin (human) — isophane/protamine zinc",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-31",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-31",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-31",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / FDA-EMA labels / VCA / EveryCat / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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