Verify Hydroxyurea (hydroxycarbamide)

Drug JSON

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{
  "slug": "hydroxyurea",
  "nameEn": "Hydroxyurea (hydroxycarbamide)",
  "nameTh": "ไฮดรอกซียูเรีย",
  "class": "Antineoplastic — ribonucleotide reductase inhibitor",
  "mechanism": "ยับยั้งเอนไซม์ ribonucleotide reductase ขัดขวางการสร้าง DNA (S-phase specific) ลดการสร้างเม็ดเลือด; ใช้คุมจำนวนเซลล์ใน polycythemia vera และ chronic leukemia",
  "brandNamesTh": [
    "Hydrea",
    "Droxia"
  ],
  "indications": [
    {
      "text": "polycythemia vera (เม็ดเลือดแดงมากผิดปกติ), chronic myelogenous leukemia, essential thrombocythemia, mastocytosis ในสุนัขและแมว — ลดจำนวนเซลล์",
      "cites": [
        "merck-polycythemia",
        "dvm360-hydroxyurea"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ ยาเคมีบำบัด PPE; กดไขกระดูก (dose-limiting) — ตรวจ CBC สม่ำเสมอ; ⚠️ ในแมวมีรายงานพิษ (methemoglobinemia, sloughing เล็บ); ปรับในไตบกพร่อง; teratogenic",
      "cites": [
        "merck-polycythemia",
        "dvm360-hydroxyurea"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "กดไขกระดูก (leukopenia/thrombocytopenia), GI upset, ผมร่วง, การเปลี่ยนแปลงผิวหนัง/เล็บ; แมวไวต่อพิษมากกว่า",
      "cites": [
        "dvm360-hydroxyurea"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Polycythemia vera / CML — specialist",
      "route": "PO",
      "dose": "30 mg/kg PO วันละครั้ง นาน 7–10 วัน แล้วลดเป็น 15 mg/kg วันละครั้ง ปรับตาม hematocrit/CBC (หรือ 40–50 mg/kg q48h)",
      "cites": [
        "merck-polycythemia",
        "dvm360-hydroxyurea"
      ]
    },
    {
      "species": "feline",
      "indication": "Polycythemia vera — specialist",
      "route": "PO",
      "dose": "15–30 mg/kg PO วันเว้นวัน หรือสัปดาห์ละ 2–3 ครั้ง ปรับตาม hematocrit — ⚠️ แมวระวังพิษ",
      "cites": [
        "dvm360-hydroxyurea"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจ CBC (RBC/WBC/platelet) สม่ำเสมอ; ปรับขนาดให้ hematocrit < 60% แล้วใช้ขนาดต่ำสุดที่คุมได้",
      "cites": [
        "merck-polycythemia"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-polycythemia",
      "type": "textbook",
      "title": "Erythrocytosis (Polycythemia) in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/circulatory-system/erythrocytosis-polycythemia/erythrocytosis-polycythemia-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "dvm360-hydroxyurea",
      "type": "guideline",
      "title": "Toxicology Brief: Hydroxyurea toxicosis in dogs and cats — dvm360",
      "url": "https://www.dvm360.com/view/toxicology-brief-hydroxyurea-toxicosis-dogs-and-cats",
      "year": 2025,
      "note": "Clinical veterinary drug reference.",
      "cid": null
    },
    {
      "id": "wikipedia-hydroxycarbamide",
      "type": "monograph",
      "title": "Hydroxycarbamide (hydroxyurea) — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Hydroxycarbamide",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "L01XX05",
      "name": "Hydroxycarbamide (hydroxyurea)",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VSSO / CURATIVE / Tufts CardioRush / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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