Verify Hydralazine

Drug JSON

This is exactly what your browser canonicalizes + SHA-256-hashes

{
  "slug": "hydralazine",
  "nameEn": "Hydralazine",
  "nameTh": "ไฮดราลาซีน",
  "class": "Cardiovascular — arteriolar vasodilator",
  "mechanism": "ขยายหลอดเลือดแดงโดยตรง (direct arteriolar vasodilator) คลายกล้ามเนื้อเรียบหลอดเลือด ลด afterload จึงลด mitral regurgitation และเพิ่ม forward stroke volume",
  "brandNamesTh": [
    "Apresoline"
  ],
  "indications": [
    {
      "text": "ลด afterload ใน mitral regurgitation รุนแรง/CHF (โดยเฉพาะจาก degenerative mitral valve disease หรือ DCM) และความดันโลหิตสูงในสุนัขและแมว — มักใช้เมื่อ ACEi ไม่พอ",
      "cites": [
        "merck-vasoactive",
        "tufts-hydralazine"
      ]
    }
  ],
  "contraindications": [
    {
      "text": "⚠️ titrate จากขนาดต่ำ เฝ้าระวัง hypotension (เป้า systolic 90–100 mmHg ใน acute CHF); reflex tachycardia + Na/water retention (อาจต้องใช้คู่ diuretic); ระวังในขาดน้ำ",
      "cites": [
        "merck-vasoactive",
        "tufts-hydralazine"
      ]
    }
  ],
  "sideEffects": [
    {
      "text": "ความดันต่ำ, หัวใจเต้นเร็วสะท้อนกลับ (reflex tachycardia), ซึม/อ่อนแรง, GI upset, คั่งน้ำ-โซเดียม",
      "cites": [
        "merck-vasoactive"
      ]
    }
  ],
  "dosages": [
    {
      "species": "canine",
      "indication": "Afterload reduction (mitral regurgitation / CHF)",
      "route": "PO",
      "dose": "0.5–2 mg/kg PO ทุก 12 ชั่วโมง (เริ่มต่ำแล้ว titrate ตามความดัน; ช่วงกว้าง 0.5–3 mg/kg)",
      "cites": [
        "merck-vasoactive",
        "tufts-hydralazine"
      ]
    },
    {
      "species": "feline",
      "indication": "Hypertension / afterload reduction",
      "route": "PO",
      "dose": "2.5 mg/ตัว PO ทุก 12 ชั่วโมง (titrate)",
      "cites": [
        "tufts-hydralazine"
      ]
    }
  ],
  "monitoring": [
    {
      "text": "ตรวจความดันโลหิต (เลี่ยง hypotension) + อัตราการเต้นหัวใจ + ค่าไตเมื่อ titrate",
      "cites": [
        "merck-vasoactive"
      ]
    }
  ],
  "citations": [
    {
      "id": "merck-vasoactive",
      "type": "textbook",
      "title": "Vasoactive Drugs for Use in Animals — MSD/Merck Veterinary Manual",
      "year": 2025,
      "url": "https://www.merckvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-cardiovascular-system/vasoactive-drugs-for-use-in-animals",
      "note": "Authoritative veterinary pharmacology reference. Copyrighted, cited not mirrored.",
      "cid": null
    },
    {
      "id": "tufts-hydralazine",
      "type": "guideline",
      "title": "Hydralazine — Tufts CardioRush Cardiology Drug Formulary",
      "url": "https://sites.tufts.edu/cardiorush/cardiology-drug-formulary/",
      "year": 2024,
      "note": "Tufts cardiology reference dosing.",
      "cid": null
    },
    {
      "id": "wikipedia-hydralazine",
      "type": "monograph",
      "title": "Hydralazine — Wikipedia",
      "year": 2026,
      "url": "https://en.wikipedia.org/wiki/Hydralazine",
      "note": "Tertiary cross-check for class + mechanism. CC BY-SA 4.0. Not sole authority.",
      "cid": null
    }
  ],
  "mirroredFrom": [
    {
      "id": "who-atc",
      "name": "WHO ATC/DDD Index",
      "url": "https://www.whocc.no/atc_ddd_index/",
      "asOfDate": "2026-05-30",
      "license": "WHO publication, free for use with attribution"
    }
  ],
  "mirrorCIDs": [],
  "codes": {
    "atc": {
      "code": "C02DB02",
      "name": "Hydralazine",
      "level": 5
    }
  },
  "drafting": {
    "aiAssisted": false,
    "aiModel": null,
    "aiPromptHash": null,
    "humanReviewer": "palmzamak2547",
    "humanReviewedAt": "2026-05-30",
    "humanEditsRatio": null
  },
  "signatures": [],
  "reviewedBy": null,
  "lastUpdated": "2026-05-30",
  "version": 1,
  "changelog": [
    {
      "version": 1,
      "date": "2026-05-30",
      "summary": "New entry — clinical content compiled from cited authoritative sources (Merck Veterinary Manual / VSSO / CURATIVE / Tufts CardioRush / Today's Vet Practice / peer-reviewed), cross-checked. Every statement cited. Reviewed by palmzamak2547. Pending faculty canonical signature."
    }
  ]
}

Public keys used

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